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Promoter for recovery from anesthesia

A technology of enhancer and corrector, applied in the field of acidosis corrector, management and promotion of recovery from anesthesia, to achieve the effect of reducing delay of recovery, stabilizing early recovery, and promoting early recovery

Inactive Publication Date: 2009-01-28
EA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the current method to speed up recovery from anesthesia is to observe the dynamics of the operation during the operation, and the depth of anesthesia (general state) for the patient in accordance with the dynamics, and to control the maintenance of anesthesia through the speed of administration, which depends on the professional anesthesiologists. experience, nothing else

Method used

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  • Promoter for recovery from anesthesia
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  • Promoter for recovery from anesthesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: preservation stability

[0060] Preparation of bicarbonate ion (HCO 3 - ) concentrations of 20.0, 22.5, 25.0, 27.5 and 30.0 mEq / L Ringer's solution, respectively.

[0061] That is, infusion solution preparations were prepared according to the formulations in Table 1 below. Dissolve each ingredient in water to make 10 L (pH measured value: 8.0), adjust to pH 6.5 by bubbling carbon dioxide, filter, fill into a 500 mL glass ampoule, and autoclave it at 115°C for 15 minutes , thus producing bicarbonate ion (HCO 3 - ) concentration adjusted to 5 kinds of Ringer's solutions of 20.0, 22.5, 25.0, 27.5 and 30.0 mEq / L.

[0062] [Table 1]

[0063]

[0064]

[0065] For these infusion solutions (Ringer's solution), pH, insoluble impurities, number of insoluble particles, content of each component, and carbon dioxide concentration in the space were measured at the beginning and after storage at room temperature for 3 months. These results are shown in Ta...

Embodiment 2

[0071] Embodiment 2: the research of the wake-up time (short-time manual operation) that uses rat partial hepatectomy model to carry out surgery)

[0072] [experiment method]

[0073] For 7-week-old SD male rats, the feeding tube indwelling in the right jugular vein was started to give 20 mL / kg / hour of the present invention containing bicarbonate ions as an anesthesia recovery agent containing the formula shown in Table 4 below. 30 minutes after the start of the administration of Ringer's solution as an accelerator, the intravenous anesthetic propofol was continuously administered at 45 mg / kg / hour. The abdomen of the rat was incised at the same time as the administration of anesthesia was started, and about 75% of the liver (left and right outer lobes and left inner lobes) were excised 15 minutes after laparotomy. Thirty minutes after the laparotomy, the abdomen was sutured, and the operation and administration of anesthesia were completed. Ringer's solution was administ...

Embodiment 3

[0088] Example 3: Research on recovery rate using rat partial hepatectomy model (long operation)

[0089] [experiment method]

[0090] For 7-week-old SD male rats, the feeding tube indwelling in the right jugular vein was started to give 20 mL / kg / hour of the present invention containing bicarbonate ions as an anesthesia recovery agent containing the formula shown in Table 4 below. Accelerator Ringer's solution, meanwhile, intravenous anesthetic propofol was continuously administered at 45 mg / kg / hour. The abdomen of the rat was incised at the same time as the administration was started, and about 75% of the liver (left and right outer lobes and left inner lobes) were excised 30 minutes after the laparotomy. At 60 minutes after laparotomy, the abdomen was sutured to end the operation. Ringer's solution and anesthesia were administered for a total of 90 minutes until 30 minutes after the end of the operation. The time from the end of anesthesia administration to the awakenin...

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Abstract

It is intended to provide a method of promoting postoperative recovery from anesthesia without resorting to experience of a skilled anesthetist; and a promoter for the recovery from anesthesia to be used in this method. A preparation for promoting recovery from anesthesia which contains bicarbonate ion having an effect of promoting recovery from anesthesia, more specifically speaking, a promoter for recovery from anesthesia which is in the form of an infusion; and a method of controlling and promoting recovery from anesthesia which comprises administering the above-described promoter for recovery from anesthesia. Preferably, a promoter for recovery from anesthesia and an agent for correcting acidosis characterized by containing bicarbonate ion in the form of sodium bicarbonate as the main component together with one component or a combination thereof selected from among an electrolyte, glucose and an amino acid.

Description

technical field [0001] The present invention relates to an anesthesia recovery accelerator for accelerating recovery from anesthesia, in particular to an anesthesia recovery accelerator for promoting recovery from anesthesia in the perioperative period. The present invention further relates to a method for managing and accelerating recovery from anesthesia by administering the recovery-promoting agent. [0002] The present invention also relates to acidosis correcting agents, and in turn to methods of maintaining blood pH at a value close to normal, managing and facilitating recovery from anesthesia. Background technique [0003] When performing various operations, it is necessary to perform the operation on the patient under anesthesia, that is, to perform the operation while the patient is anesthetized during the perioperative period. In this case, anesthesia for surgery is roughly divided into general anesthesia and local anesthesia. [0004] General anesthesia is carri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/08A61K47/04A61K47/26A61K47/18A61P25/02A61P25/26
CPCA61K9/0019A61K33/00A61K47/183A61K31/7004A61K47/02A61K47/26A61K31/195A61P25/00A61P25/02A61P25/26A61P3/12A61P41/00A61P43/00A61K2300/00A61K33/10A61K47/18
Inventor 佐藤和纪小川隆神山哲哉森砂织
Owner EA PHARMA CO LTD
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