Methods and biomarkers for diagnosing and monitoring psychotic disorders such as schizophrenia

A biomarker, mental disorder technology, used in the diagnosis or monitoring of mental disorders, which can solve problems such as indeterminacy

Inactive Publication Date: 2009-01-28
PSYNOVA NEUROTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it has not been determined whether these metabolic changes are the cause of the disease or the effect of the disease itself, or whether they are the result of drug treatment

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  • Methods and biomarkers for diagnosing and monitoring psychotic disorders such as schizophrenia
  • Methods and biomarkers for diagnosing and monitoring psychotic disorders such as schizophrenia
  • Methods and biomarkers for diagnosing and monitoring psychotic disorders such as schizophrenia

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Embodiment Construction

[0111] The term "biomarker" means a distinctive biomarker or biogenic marker of a process, event or condition. Biomarker peptides can be used in diagnostic methods such as clinical screening and in prognostic assessment; and can be used to monitor treatment effects, identify patients most likely to respond to a particular therapy, screen and develop drugs. Biomarkers and their uses are valuable both for the identification of novel drug therapies and for the discovery of new targets for drug therapies.

[0112] The term thyroid hormone binding peptide biomarker includes mature full length human thyroid hormone binding peptide. A preferred thyroid hormone binding peptide biomarker (SEQ ID NO: 1 ) is or is derived from human thyroid hormone binding protein. The peptide of SEQ ID NO: 1 is the secreted form that does not contain the signal (leader) sequence present in the precursor. Also included are isoforms and derivatives of thyroid hormone binding protein, such as S-cysteinyl...

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Abstract

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1, VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.

Description

technical field [0001] The present invention relates to methods of diagnosing or monitoring psychiatric disorders, in particular, for example, methods of diagnosing or monitoring schizophrenic disorders (and bipolar disorders) using biomarkers. The biomarkers and methods using the biomarkers can be used to aid in the diagnosis and assessment of the onset and progression of mental disorders. The present invention also relates to the use of biomarkers in clinical screening, prognosis assessment, treatment evaluation, drug screening and drug development. Background technique [0002] Psychosis is a symptom of a serious mental illness. Although it is not associated with any particular psychological or physical state, it is particularly associated with schizophrenia, bipolar disorder (manic-depressive disorder), and major clinical depression. Psychosis is characterized by disturbances in basic perceptual, cognitive, affective, and intellectual processes. Individuals who experi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/465
Inventor S·巴恩J·J·黄T·曾
Owner PSYNOVA NEUROTECH LTD
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