Methods and biomarkers for diagnosing and monitoring psychotic disorders such as schizophrenia

A biomarker, mental disorder technology, used in the diagnosis or monitoring of mental disorders, which can solve problems such as indeterminacy
CN101356446AInactive Publication Date: 2009-01-28PSYNOVA NEUROTECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PSYNOVA NEUROTECH LTD
Publication Date
2009-01-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control spectra. The invention also relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarkers present in a biological sample taken from a test subject, said biomarkers being selected from the group consisting of transthyretin, ApoA1, VLDL, LDL and aromatic species such as plasma proteins. The invention also relates to sensors, biosensors, multi-analyte panels, arrays, assays and kits for performing methods of the invention.
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Description

technical field

[0001] The present invention relates to methods of diagnosing or monitoring psychiatric disorders, in particular, for example, methods of diagnosing or monitoring schizophrenic disorders (and bipolar disorders) using biomarkers. The biomarkers and methods using the biomarkers can be used to aid in the diagnosis and assessment of the onset and progression of mental disorders. The present invention also relates to the use of biomarkers in clinical screening, prognosis assessment, treatment evaluation, drug screening and drug development. Background technique

[0002] Psychosis is a symptom of a serious mental illness. Although it is not associated with any particular psychological or physical state, it is particularly associated with schizophrenia, bipolar disorder (manic-depressive disorder), and major clinical depression. Psychosis is characterized by disturbances in basic perceptual, cognitive, affective, and intellectual processes. Individuals who experi...

Claims

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