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Preparation method of hemostasia material

A hemostatic material and organic solution technology, applied in the field of hemostatic material preparation, can solve the problems of low water absorption rate and slow blood absorption rate, and achieve the effect of reducing scars, inhibiting bleeding, and improving the endogenous repair process

Inactive Publication Date: 2011-06-08
北京东方康桥医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the low water absorption rate of the hemostatic material in the prior art, resulting in a relatively slow blood absorption rate, and to provide a method for preparing a hemostatic material with a high water absorption rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This example is used to illustrate the preparation of the hemostatic material provided by the present invention.

[0037] (1) At 25°C, 5 grams of soluble starch (Sinopharm Chemical Reagent Co., Ltd., analytically pure) was mixed with 15 grams of water, stirred to make it fully mixed, and the pH value of the mixture of the starch and water was adjusted to be 9, The aqueous starch solution was then mixed with 0.005 g of octanol and allowed to stand for 5 days.

[0038] (2) At 60°C, the above-mentioned reactant containing starch, water and additives, phosphate ester MP-1 containing 2% by weight (purchased from Shuangyi Fine Chemical Factory, Zhangdian, Zibo City) and 98% by weight of paraffin oil The organic solution and epichlorohydrin were mixed and stirred for 30 minutes, and the weight ratio of starch, water, organic solution containing phosphate ester and paraffin oil to epichlorohydrin was 1:3:10:0.2. Then stand still and filter, the separated solid product is washe...

Embodiment 2

[0040] This example is used to illustrate the preparation of the hemostatic material provided by the present invention.

[0041] The hemostatic material was prepared according to the method of Example 1, except that in step (1), the aqueous starch solution and lauryl alcohol were mixed and allowed to stand for 5 days. A2 was obtained as a white powder.

Embodiment 3

[0043] This example is used to illustrate the preparation of the hemostatic material provided by the present invention.

[0044] The hemostatic material was prepared according to the method of Example 1, except that the aqueous starch solution was mixed with 0.05 g of octanol and left to stand for 5 days. A3 is obtained as a white powder.

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PUM

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Abstract

The invention relates to a preparation method of hemostatic material. The method comprises the following steps: reactant and cross linker reacts in organic solution, obtained resultant of reaction is carried out with solid-liquid separation and is dried to separate solid production, and the reactant contains amylum and water, wherein the organic solution is solution containing organic phosphate and / or organic phosphate salt and organic solvent. The hemostatic material prepared by adopting the method of the invention has higher water uptake speed and can play the role of fast hemostasia in the practical application.

Description

technical field [0001] The invention relates to a preparation method of a hemostatic material. Background technique [0002] At present, many new wound hemostatic materials have been developed at home and abroad, mainly including gelatin protein, fibrin glue, soluble hemostatic gauze, zeolite and degradable hemostatic materials. (1) Gelatin protein includes gelatin sponge, microcrystalline collagen and coagulated gelatin sponge, etc. These kinds of hemostatic materials have slow hemostatic speed, poor pulling ability to blood components such as platelets and poor adhesion to wound tissue, and are easy to break. (2) Fibrin glue has been widely used clinically as a wound hemostatic adhesive material. Its disadvantages as a wound first aid material are high cost, possible infection of human or animal blood-borne diseases, complicated use, slow hemostasis speed, and low success rate of hemostasis for large blood vessel bleeding. (3) Soluble hemostatic gauze belongs to the hemo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28
Inventor 孟建文赵伟朱肖杰池文强朱小敏
Owner 北京东方康桥医药科技有限公司
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