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Method for preparing dihydro ginsenoside Rg2 and use thereof

A technology of ginsenoside and dihydrogen, which is applied in the field of panaxatriol saponins to achieve the effects of improving auricle microcirculation, increasing strength, increasing blood flow velocity and the number of mesh points

Inactive Publication Date: 2009-04-01
GUANGZHOU TIANAN MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ginsenoside Rg2 has an unsaturated bond (double bond) in the side chain, and there is no article on the hydrogenation of the double bond at the end of the side chain to report

Method used

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  • Method for preparing dihydro ginsenoside Rg2 and use thereof
  • Method for preparing dihydro ginsenoside Rg2 and use thereof
  • Method for preparing dihydro ginsenoside Rg2 and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Weigh raw material ginsenoside Rg 2 500 mg was placed in a 50 ml round bottom flask, an appropriate amount of methanol was added to dissolve it, 100 mg of palladium carbon was added, and hydrogen gas was continuously passed into the bottom of the solution; stirred at room temperature, filtered, concentrated, and dried under reduced pressure to obtain a mixed configuration (20S, R) Hydrogen Ginsenoside Rg 2 450mg.

Embodiment 2

[0090] Weigh raw material ginsenoside Rg 2 600 mg was placed in an 80 ml round-bottomed flask, an appropriate amount of methanol was added to dissolve it, 120 mg of palladium carbon was added, and hydrogen gas was continuously passed into the bottom of the solution; stirred at room temperature, filtered, concentrated, and dried under reduced pressure to obtain a mixed configuration (20S, R) Hydrogen Ginsenoside Rg 2 550mg.

Embodiment 3

[0092] Weigh raw material ginsenoside Rg 2 400mg, put in a 40ml round bottom flask, add an appropriate amount of methanol to dissolve, add 80mg of palladium carbon, and continuously pass hydrogen into the bottom of the solution; stir at room temperature, filter, concentrate, and dry under reduced pressure to obtain a mixed configuration (20S, R) Hydrogen Ginsenoside Rg 2 350mg.

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Abstract

The invention discloses a preparation method of a novel ginsenoside--dihydro ginsenoside Rg2, which has more than 80 percent of yield and is suitable for industrial production. The dihydro ginsenoside Rg2 has the functions of preventing or treating diseases related to microcirculatory disturbance.

Description

technical field [0001] The present invention relates to a novel ginseng triol saponin compound - dihydroginsenoside Rg 2 And its preparation method and use. Background technique [0002] Ginseng is a perennial herb of the Araliaceae family. The medicinal parts are mainly the roots and whiskers of ginseng. Now, ginseng leaves and buds are also used for medicinal purposes. In my country, ginseng has been used as a traditional Chinese medicine in clinical medicine for thousands of years. According to traditional Chinese medicine theory, its main effects are to replenish vitality, nourish the spleen and lungs, soothe the nerves and improve the mind, and promote body fluid to quench thirst. The main components included in ginseng are ginsenosides, ginseng polysaccharides, ginseng alcohol, volatile oil, low molecular weight peptides, amino acids, vitamins, organic acids and various trace elements. Modern medicine has also proved that in addition to nourishing and strengthening t...

Claims

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Application Information

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IPC IPC(8): C07J17/00A61K31/704A61P9/10A61P25/28A61P3/10
Inventor 姜志宏李龙云李浩
Owner GUANGZHOU TIANAN MEDICAL TECH
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