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Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators

A technology of composition and regulator, which can be applied in the directions of drug combination, medical preparation containing active ingredient, active ingredient of hydroxyl compound, etc., and can solve the problem of undiscovered coronary heart disease, heart condition, etc.

Inactive Publication Date: 2009-05-13
SOLVAY PHARMA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to information from the American Heart Association, the term "Syndrome X" additionally refers to a cardiac condition in which there is chest pain and ECG changes suggestive of ischemic heart disease, but no coronary artery disease is detected on angiography

Method used

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  • Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
  • Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
  • Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Example 1: Containing K ATP Channel Modulators and CBs x Regulator capsules

[0115] 4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazole-1- 50mg

[0116] base]-methylamino-methylene}-benzenesulfonamide

[0117] 3-(1,1-Dimethyl-butyl)-6,6,9-trimethyl-6a, 7, 10, 10a- 50mg

[0118] Tetrahydro-6H-benzo[c]chromene (JW133)

[0119] Corn starch 150mg

[0120] Lactose 150mg

[0121] Proper amount of ethyl acetate

Embodiment 2

[0122] Embodiment 2: Contain K ATP Channel Modulators and CBs x Regulator capsules

[0123] N-{amino-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazole- 50mg

[0124] 1-yl]-methylene}-4-chloro-benzenesulfonamide

[0125] 3-(1,1-Dimethyl-butyl)-6,6,9-trimethyl-6a, 7, 10, 10a- 50mg

[0126] Tetrahydro-6H-benzo[c]chromene (JW133)

[0127] Corn starch 150mg

[0128] Lactose 150mg

[0129] Proper amount of ethyl acetate

Embodiment 3

[0130] Embodiment 3: Contain K ATP Channel Modulators and CBs x Regulator capsules

[0131] N-{[3-(4-chloro-phenyl)-4-pyridin-3-yl-4,5-dihydro-pyrazole- 50mg

[0132] 1-yl]-methylamino-methylene}-4-trifluoromethyl-benzenesulfonamide

[0133] 3-(1,1-Dimethyl-butyl)-6,6,9-trimethyl-6a, 7, 10, 10a- 50mg

[0134] Tetrahydro-6H-benzo[c]chromene (JW133)

[0135] Corn starch 150mg

[0136] Lactose 150mg

[0137] Proper amount of ethyl acetate

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PUM

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Abstract

The invention is directed to pharmaceutical compositions comprising pharmacologically effective quantities of each of a) at least one KATP channel modulator as a first active agent and b) at least one CBx modulator as a second active agent. The invention further relates to the use of such compositions and to methods of treating, preventing, delaying progression of, delaying onset of and / or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans by administering such compositions to subjects in need thereof. The invention also is directed to processes of manufacturing such compositions.

Description

technical field [0001] The present invention relates to novel combination treatments for a variety of disease conditions in mammals and humans, including obesity, diabetes, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulinemic hypoglycemia, male Alopecia pattern, detrusor hyperactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina pectoris, cardioplegia, arrhythmia, coronary artery spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, Pain - including neuropathic pain and chronic pain - and impotence. The present invention also relates to ATP Channel Modulators and CBs x Novel pharmaceutical compositions of modulators and said pharmaceutical compositions for preventing various disease states, treating various disease states, delaying the progression of various disease states, delaying the onset of various disease states and / or inhibiting various disease states conditions including obesity, d...

Claims

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Application Information

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IPC IPC(8): A61K31/415A61K31/426A61K31/045A61P9/00A61P3/00
CPCA61K31/045A61K31/426A61K31/415A61P11/06A61P13/02A61P15/10A61P17/14A61P19/06A61P25/00A61P25/04A61P25/08A61P3/00A61P3/10A61P3/04A61P3/08A61P9/00A61P9/04A61P9/06A61P9/10A61P9/12A61K2300/00
Inventor J·安特尔P-C·格雷戈里J·H·M·朗格M·菲尔吉斯D·莱舍
Owner SOLVAY PHARMA GMBH
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