Use of basket fern in preparing medicament for preventing and treating systemic lupus erythematosus

A systemic technique for lupus erythematosus, which is applied in the preparation of systemic lupus erythematosus medicines by the total polysaccharide of the traditional Chinese medicine, and the new medicinal use field of the total polysaccharide of the traditional Chinese medicine, and can solve the systemic lupus erythematosus medicines that have not yet been reported. efficacy and drugs

Inactive Publication Date: 2009-07-08
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Throughout the research at home and abroad, there is no report on the efficacy of the total polysaccharides in the prevention and treatment of systemic lupus erythematosus and its medicinal properties.

Method used

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  • Use of basket fern in preparing medicament for preventing and treating systemic lupus erythematosus
  • Use of basket fern in preparing medicament for preventing and treating systemic lupus erythematosus
  • Use of basket fern in preparing medicament for preventing and treating systemic lupus erythematosus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 100g of Guanzhong medicinal materials, extracted by cold soaking with 95% ethanol, the dregs were placed in a ventilated place at room temperature to dry, then extracted with hot water for 3 times, filtered, combined extracts, concentrated, centrifuged, and the supernatant was washed with S trichloro Remove free protein with acetic acid, centrifuge, dialyze the supernatant with water for 3 days, concentrate the dialysate to a small volume, add ethanol to an alcohol content of 80%, centrifuge, precipitate and freeze-dry to obtain the total polysaccharide, the product yield is more than 5%, and the polysaccharide content More than 50%. Table 1 is the yield and content of the total polysaccharides in Guanzhong.

[0033] Table 1

[0034]

Embodiment 2

[0036]Thirty Kunming mice (16-20g) were randomly divided into 5 groups (groups A, B, C, D, and E). Group A is the normal control group, group B is the model control group, group C is the SLE model group, group D is the Guanzhongsugar group, and group E is the prednisone acetate group. For the initial immunization, group A was the normal control group, with saline injected subcutaneously at the base of the tail, group B was the model control group, and Freund's complete adjuvant was injected subcutaneously at the base of the tail, and the rest of the groups were subcutaneously injected with Campylobacter jejuni and complete Freund's adjuvant at the base of the tail. Injection, immunization induces SLE-like syndrome, and the injection volume of each mouse is 50 μl. On the 14th day after the initial immunization, booster immunization was given once: groups A and B were subcutaneously injected with normal saline, and the rest of the groups were subcutaneously injected with Campylo...

Embodiment 3

[0045] Forty-eight BALB / c mice (16-20g) were randomly divided into 5 groups (groups A, B, C, D, and E). Group A is the normal control group (n=8), group B is the model control group (n=8), group C is the SLE model group (n=10), group D is the sugar group (n=9), E The group was prednisone acetate group (n=8). For the initial immunization, group A was the normal control group with subcutaneous injection of normal saline in the footstones, group B was the model control group with subcutaneous injection of Freund's complete adjuvant in the footstones, and the rest of the groups were injected with Campylobacter jejuni combined with complete Freund's adjuvant. Subcutaneous injection of stoneware to induce SLE-like syndrome by immunization, with an injection volume of 50 μl per mouse. On the 14th day after the initial immunization, a booster immunization was given once: groups A and B were injected with normal saline through the tail vein, and the other groups were injected with Cam...

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Abstract

The invention belongs to the field of traditional Chinese medicine, relating to the usage of cyrtomium rhizome total polysaccharides for preparing a drug preventing and curing systemic lupus erythematosus. In the invention, total polysaccharide extracts are separated and extracted from the traditional Chinese medicine cyrtomium rhizome, product yield thereof averages 5.72% and polysaccharide content thereof exceeds 50%; An integral animal model test result shows that the total polysaccharides have an obvious protection effect on autoimmune response hyper-function and renal injury of mice with systemic lupus erythematous syndrome. The test demonstrates that the total polysaccharides can prevent and cure systemic lupus erythematous syndrome and be applicable for preparing the drug preventing and curing systemic lupus erythematosus and auto-immune diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a new medical application of polysaccharides of the traditional Chinese medicine Guanzhong. It specifically relates to the use of the total polysaccharides in the preparation of systemic lupus erythematosus medicaments. Background technique: [0002] Systemic lupus erythematosus (SLE) is an inflammatory connective tissue disease of unknown etiology, mainly affecting women, but can also affect children. A multi-country and multi-center study showed that the current incidence of systemic lupus erythematosus ranges from 12.5 / 100,000 to 39 / 100,000. SLE is a severe autoimmune disease with refractory, recurrent attacks and high fatality rate. It is often regarded as a representative autoimmune disease. The phenotypes of SLE autoimmune abnormalities are highly diverse, including immune tolerance defect, lymphocyte apoptosis disorder, T or B cell function regulation disorder,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P19/04A61P29/00A61P37/02
Inventor 陈道峰力弘王铮徐晗卢燕
Owner FUDAN UNIV
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