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Oleum fructus bruceae preparation and preparation method thereof

A technology of bruce japonica oil and bruce chinensis, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, and can solve problems such as the lack of development of drop pills.

Inactive Publication Date: 2009-08-05
张芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1933, the Danish Ferrossam Pharmaceutical Company developed vitamin AD drop pills for the first time, but at that time, due to the limitations of scientific research, production technology and additives, the drop pills did not develop

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 750 drop pills Prescription: Brucea javanica oil 100ml

[0017] Sodium stearate 22g

[0018] Insect Wax 5g

[0019] Condensate: water

[0020] Preparation process: accurately take by weighing sodium stearate 22g, worm wax 5g, heat to melting, stir, constant temperature, standby; Measure the javanica javanica oil of recipe quantity and add in the matrix of melting, stir until homogeneous liquid medicine, constant temperature (80 ℃), use a self-made or general-purpose dropping pill machine, adjust the size of the dripper and the distance from the condensate, drop the liquid medicine into the water at a dropping speed of 40-45 drops per minute, take out the formed dropping pills, and remove the surface The condensate is dried, inspected and packaged.

Embodiment 2

[0022] 750 drop pills Prescription: Brucea javanica oil 100ml

[0023] Macrogol 6000 110g

[0024] Stearic acid 25g

[0025] Condensate: Simethicone

[0026] Preparation process: Accurately weigh polyethylene glycol 6000110g, stearic acid 25g, heat to melt, stir well, constant temperature, and set aside; measure the javanica javanica oil of the prescription amount and add it to the molten matrix, stir until uniform medicinal solution, constant temperature ( 80°C), using a self-made or general-purpose dropping pill machine, adjust the size of the dripper and the distance from the condensate, drop the drug liquid into the simethicone at a dropping speed of 35-40 drops per minute, and take out the formed dropping pills , remove the condensate on the surface, dry, inspect and pack.

Embodiment 3

[0028] 750 drop pills Prescription: Brucea javanica oil 100ml

[0029] Macrogol 10000 120g

[0030] Condensate: Simethicone

[0031] Preparation process: Accurately weigh 10000120g of polyethylene glycol, heat and stir until melting, keep the temperature (100°C), and set aside; measure the prescription amount of javanica javanica oil and add it to the molten matrix, stir until the liquid is uniform, keep the temperature (80°C) , use a self-made or general-purpose dropping pill machine, adjust the size of the dripper and the distance from the condensate, drop the liquid medicine into the simethicone at a dripping speed of 35-40 drops per minute, take out the formed dropping pills, and remove the surface The condensate is dried, inspected and packaged.

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PUM

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Abstract

The invention discloses an adjuvant therapeutic medicine composition, namely a brucea fruit oil dripping pill or an enteric dripping pill, for lung cancer, brain metastasis of lung cancer, digestive tract tumor and liver cancer, and a preparation method thereof. The preparation method is characterized in that brucea fruit oil is taken as a raw material and prepared into a dripping pill or the enteric dripping pill with a pharmaceutically acceptable substrate or a pharmaceutically acceptable additive, and each dripping pill or each enteric dripping pill contains 0.02 to 2 milliliters of the brucea fruit oil. The adjuvant therapeutic medicine composition improves the leachability of medicines, increases the stability of the medicines, reduces untoward reactions of the medicines, provides convenience for carrying and taking of the medicines, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for adjuvant treatment of lung cancer, brain metastases of lung cancer, gastrointestinal tumors and liver cancer and a preparation method thereof. Background technique [0002] Brucea javanica oil is the fatty oil obtained from the dried and mature fruit of Brucea javanical[L]Merr, a plant of the family Kuaceae, extracted with petroleum ether. The total acid content calculated by oleic acid shall not be less than 90.0% (Ministry of Public Health Drug Standards of the People's Republic of China Traditional Chinese Medicine Prescriptions Volume 14 Page 103). Brucea javanica oil is a brownish-yellow, clear oily liquid, the main active ingredients of which are oleic acid and linoleic acid, both of which are unsaturated fatty acids, and are considered to be anti-tumor active ingredients. [0003] Present clinical application preparations of Br...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/20A61K9/34A61K9/36A61K9/40A61P35/00A61P35/04
Inventor 张芳李俊逸许韫张永清周凤琴于晓
Owner 张芳
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