Lipid nano granule containing magnetic resonance contrast agent as well as preparation method and use thereof

Abstract

The invention provides a lipid nano-particle which is easy to absorb by an intestinal tract, wherein a magnetic resonance contrast agent, namely gadolinium diethylenetriaminepentaacetic acid (Gd-DTBA) is loaded, and glyceryl monostearate and lecithin are taken as lipid materials. The invention applies lipidosome nano-particles which are easy to absorb by the intestinal tract to enveloping the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is clinically used most commonly to ensure that the magnetic resonance contrast agent, namely the gadolinium diethylenetriaminepentaacetic acid which is not absorbed by a digestive canal can be absorbed into an intestinal wall in a large quantity to make the intestinal wall produce MRI enhancement, displays pathological changes through the difference of normal intestinal walls and the pathological changes on the absorption and distribution of the lipid nano-particle, and can reflect the absorption function condition of the lipid nano-particle caused by the pathological changes. The method has the following advantages: the local administration is performed, and no intravenous and systemic administration are needed; the method may realize the evaluation of an intestinal absorption function; the nano-particle enters cells to realize the horizontal visualization of the cells; and the nano-particle mainly adopts lymph transport and can realize lymphatic imaging which are favorable for the lymphatic target display of intestinal pathological changes.

Description

technical field [0001] The invention relates to a lipid nanoparticle loaded with a magnetic resonance contrast agent, a preparation method thereof and an application in intestinal magnetic resonance imaging. Background technique [0002] Various imaging methods, including barium double contrast radiography, CT, and MRI, all play an important role in the examination of intestinal lesions. The various positive contrast agents involved, such as barium, iodine-containing contrast, and gadopentetate meglumine (Gd-DTPA), are not easily absorbed or cannot be absorbed by the digestive tract. Compared with CT, MRI has extremely high soft tissue resolution and no radiation, so it has attracted much attention in the examination of intestinal lesions in recent years. The most widely used clinical MR contrast agent is Gd-DTPA. Gd-DTPA is a positive contrast agent and is not absorbed by the digestive tract. There are two main methods of its application in the digestive tract. The firs...

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Problems solved by technology

The first method has a low detection rate for small lesions, and it is difficult to distinguish small lesions of mucosal origin from intestinal contents

The second method is better than the first method for lesion detection and lesion characterization. However, after intravenous administration, it is distributed throughout the body without tissue and organ targeting and specificity. It is distributed in the intercellular space and cannot enter the cell. Distribution is only related to blood supply, and has no targeting and specificity for lesions

At present, there are some research reports on the use of liposome-encapsulated Gd-DTPA, which is mainly used in intravenous injection to change the distribution of gadopentetate meglumine in the body and improve the imaging ability of target tissues, but the use of lipid nanoparticles Wrapping shows Gd-DTPA, and its application in intestinal absorption imaging has not been reported yet

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