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Chinese herbal main component prescription for curing fatty liver

A technology of fatty liver and traditional Chinese medicine, which is applied in the direction of drug combination, medical formula, organic active ingredients, etc., can solve the problems of too many prescription drugs and difficult quality assurance, and achieve the goal of less prescription ingredients, sure curative effect, and improvement of fatty liver treatment Effect

Inactive Publication Date: 2009-09-09
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are a large number of literature reports that traditional Chinese medicine compound can prevent and treat fatty liver, but there are many prescription drugs, generally at least 5 to 10 traditional Chinese medicines, and as many as 10 traditional Chinese medicines, and most of them are self-purchased and self-decocted, so the quality is difficult to guarantee

Method used

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  • Chinese herbal main component prescription for curing fatty liver
  • Chinese herbal main component prescription for curing fatty liver
  • Chinese herbal main component prescription for curing fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Establish an in vitro liver cell line (L02) steatosis model, observe the main components of this traditional Chinese medicine (ginseng stem and leaf saponins, Panax notoginseng saponins, and gastrodin are purified standard products of main components of traditional Chinese medicine, purchased from the National Institute for the Control of Pharmaceutical and Biological Products) For the protective effect of ethanol-induced liver cell damage and the content of triglyceride (TG) in liver cells, orthogonal experiments were used to screen out the main components of traditional Chinese medicine and determine the optimal dosage; and to explore its effect on fatty degeneration of liver cell lines Mechanism of action research.

[0022] 1. Establishment of a liver cell line (L02) steatosis model in vitro

[0023] Determination of the concentration of ethanol: take the L02 cells in the logarithmic growth phase, and adjust the cell concentration to 5×10 4 cells / mL, take 200 μL of ...

Embodiment 2

[0076] Using mice with hyperlipidemic fatty liver as a model to verify the therapeutic effect of the main components of traditional Chinese medicine on fatty liver

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PUM

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Abstract

The invention discloses a Chinese herbal main component prescription for curing fatty liver, which contains the following the effective components based on the weight ratio: 0.01-50g of ginseng stem leaf saponin, 0.01-50g of panax notoginseng saponins and 0.01-50g of gastrodin. By adopting a conventional processing method, the component prescription can be manufactured into injectins, oral liquid, capsules or tablets. The Chinese herbal main component prescription has obvious effects for curing hyperlipidemia fatty liver and improving and culturing fatty degeneration of liver cells, looks for entry points for merging two different medical theory systems of Chinese and Western medicine, and has an important clinic application value for fatty liver prevention and cure; the research fruits can be used for developing modern Chinese herbal active ingredient products for curing the fatty liver, and lays a good foundation for developing modern prepared Chinese herb for curing the fatty liver with independent intellectual property rights; and the Chinese herbal main component prescription has small ingredients, easy separation and extraction, positive efficacy, good market prospect, and a certain practical significance for promoting the modernization of Chinese herb.

Description

technical field [0001] The invention belongs to the field of research, development and utilization of traditional Chinese medicine, and in particular relates to a prescription of main components of traditional Chinese medicine (main components are ginseng stem and leaf saponins, panax notoginseng saponins and gastrodin) for treating fatty liver. Background technique [0002] Fatty liver is a liver disease caused by one or more reasons and the pathological change is the accumulation of liver lipids (usually triglycerides). With the changes in the diet structure of our people and the improvement of medical imaging technology, the diagnosis rate of fatty liver in our country is increasing year by year. According to whether drinking alcohol or not, fatty liver is divided into alcoholic fatty liver and non-alcoholic fatty liver. Non-alcoholic fatty liver can develop into irreversible liver damage in a relatively short period of time, the incidence of liver fibrosis is as high as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P1/16A61K31/7034
Inventor 胡巢凤陆大祥戚仁斌
Owner JINAN UNIVERSITY
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