Enteric sustained and controlled release capsule

Abstract

The invention relates to an enteric sustained and controlled release capsule which is characterized by comprising the following therapeutic medicines by the weight percent: 70 to 80 of berberis pruinosa and 20 to 30 of baikal skullcap roots, wherein the berberis pruinosa is extracted by alcohol, the baikal skullcap roots are extracted partially by water and are partially crushed into fine powder, after being mixed, alcohol extract liquid and water extract liquid are condensed into clear paste, the clear paste is mixed with the fine powder to prepare film coating medicine micro-capsules with grain diameters being 200 to 2000 micrometers, and the micro-capsules are divided into different shares and are respectively used for coating enteric target controlled release capsules which are dissolved by a solution with different pH values and formed by combining high molecular material enteric coatings and biodegradation controlled release structures, so the micro-capsules can evenly release in different enteric canals. The enteric sustained and controlled release capsule avoids the defect that the common preparation taken by a patient can generate a peak-valley phenomenon. Under the circulation of the enteric canal of a human body, the micro-capsules can release in different physiologic regions in a gradient way; and when arriving at the colon region, the micro-capsules can accelerate releasing under the degradation of specific enzyme to improve the curative effect.

Description

technical field [0001] The invention belongs to the category of enteric medicine, in particular to an intestinal sustained-release and controlled-release capsule. Background technique [0002] When traditional oral administration preparations need to exert their medicinal effects in the intestinal tract, the existing technology often wraps the pharmaceutical preparations with an enteric coating, relying on the difference in pH between the stomach and the intestinal tract under physiological conditions, so that the coated drugs will remain in the stomach. Insoluble but dissolved in the intestinal tract to play a medicinal effect. [0003] However, the physiological pH in the intestinal tract is also different, such as the pH of the duodenum is about 6.6; the pH of the jejunum is about 7.4; the pH of the ileum is about 7.5; the pH of the colon is about 6.6. And in some pathological conditions, the pH value of different intestinal parts changes; the coating film that is expect...

AI Technical Summary

Problems solved by technology

And in some pathological conditions, the pH value of different intestinal parts changes; the coating film that is expected to be dissolved in a specific part of the intestinal tract is not dissolved in time, so the simple pH-dependent enteric coating film is used alone, Targeted drug delivery is less effective

A simple pH-dependent enteric coating is difficult to meet the needs of drug release in different intestinal sites

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