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Application of ginseng alkynol in pharmacy

A panaxynol and drug technology, applied in the field of medicine, can solve the problems of seriousness, limited clinical application, numerous adverse reactions of glucocorticoids, etc., and achieve the effects of inhibiting the secretion of IFN-γ and reducing the inflammatory response

Inactive Publication Date: 2011-01-19
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, glucocorticoid is a commonly used powerful anti-allergic drug, which has strong anti-inflammatory, anti-allergic, and immunosuppressive effects. Hormone cannot fundamentally solve the problem of disease recurrence, so it is only used clinically for severe and acute patients, and its clinical application is relatively limited

Method used

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  • Application of ginseng alkynol in pharmacy
  • Application of ginseng alkynol in pharmacy
  • Application of ginseng alkynol in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 panaxynol-extracting and separating from the windproof medicinal material

[0033] Take 4500g of windproof medicinal material, put it in an extraction container, add 95% ethanol until the liquid surface just covers the surface of the medicinal material, soak at room temperature, stir regularly, filter out the extract after 24 hours, soak and extract for 3 times, combine the extract, and reduce the temperature at 60°C Press and recover the ethanol until there is no alcohol smell, and obtain the extract of the alcohol extraction part of Fangfeng (extract weight: 194.88g), add appropriate amount of water to disperse and dissolve, extract with the same amount of petroleum ether, extract 3 times in total, combine the petroleum ether layer, and heat at 60°C Recover the solvent under reduced pressure to obtain petroleum ether part extract (extract weight: 87.76g).

[0034] Weigh 80g of extract from the petroleum ether part of Fangfeng, mix well ...

Embodiment 2

[0035] Preparation of Example 2 Panaxynol - Extraction and Separation from Radix Notoginseng Medicinal Materials

[0036] with supercritical CO 2 Extraction method for extraction, conditions: extraction kettle: extraction pressure 30MPa, extraction temperature 48°C; separation kettle I: pressure 8MPa, separation temperature 30°C; separation kettle II: pressure 5MPa, separation temperature 30°C; extraction time 2.0h; CO 2 The flow rate is 35L / h; the Panax notoginseng particles pass through a 60-mesh sieve.

[0037] The pulverized notoginseng medicinal material is put into the extraction kettle, the extraction kettle and the separation kettle are heated respectively, and the refrigerator is cooled. When the selected temperature is reached, the CO is turned on 2Cylinders, the system is pressurized by a high pressure pump. When the extraction tank, separation tank I, and separation tank II respectively reach the selected pressure, close the CO 2 The steel cylinder starts to ci...

Embodiment 3

[0038] Example 3 Effect of Panaxynol on Allergic Contact Dermatitis Mouse Model

[0039] METHODS: ICR clean level mice were adaptively fed for 3 days and divided into 4 groups, namely Panaxynol group (10mg / kg), Yupingfeng powder alcohol extract group (13g crude drug / kg), Dexamethasone group ( 24mg·kg) and the model group. Panaxynol (intraperitoneal injection) and Yupingfeng powder alcohol extract group (gastric administration) were administered daily from the first day of modeling, and stopped on the day before the challenge; the dexamethasone group was administered from the first day of modeling From day 1 to day 8, intraperitoneal injection was administered every day. On the first day of the experiment, shave about 2×2 cm on the abdomen of the mouse 2 On the 2nd and 3rd day, 80 μl of 5% (5g / 100ml) DNCB acetone solution was applied to the shaved area, and on the 7th day, 50 μl of 1% (1g / 100ml) DNCB acetone solution was applied to the left ear for attack. An acetone solutio...

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Abstract

The invention relates to the application of ginseng alkynol for preparing medicine treating delayed hypersensitivity diseases, in particular to the application of the ginseng alkynol for preparing the medicine treating contact dermatitis, the application of the ginseng alkynol for preparing the medicine treating hypersensitivity pneumonia, the application of the ginseng alkynol for preparing the medicine treating homograft rejection, and the application of the ginseng alkynol for preparing the medicine treating granulomatosis caused by pathogene in cells. The ginseng alkynol is used as main active ingredient used for treating the delayed hypersensitivity diseases, can obviously inhibit the diseases mediated by delayed hypersensitivity, has no obvious inhibition to immune organs and other cells, and is hopeful to be higher effective and lower toxic medicine used for treating the delayed hypersensitivity diseases.

Description

1. Technical field [0001] The present invention relates to the application of panaxynol, in particular to its application in the field of medicine. 2. Background technology [0002] Prior Art: Delayed type hypersensitivity (DTH, also known as type IV hypersensitivity) includes the immune response mediated by sensitized T cells and the resulting tissue and cell damage. Cellular immunity refers to the host immune response that stimulates the local production of cytokines in the presence of antigens and is characterized by the proliferation of specific T cells. These cytokines attract monocytes from the blood to the site of damage and activate the immune process. DTH is an immune response process similar to the cellular immune process that includes the action of T cells and cytokines. The expression of DTH depends largely on the cytokines released by Th1 cells, so the induction of Th1 is of signal importance. Th1 is activated by recognizing the complex of MHC class II molecu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61P37/00A61P17/00A61P29/00A61P11/00A61P37/06
Inventor 洪敏文红梅华永庆
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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