Compound antibacterial injection for livestock and preparation method thereof
An injection and compound technology, which is applied in the directions of antibacterial drugs, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem that the stability of the injection is not good enough, the drug cannot be absorbed for a long time, and the curative effect of the drug is affected. To achieve the effect of prolonging the maintenance time of effective blood drug concentration, improving clarity, saving manpower and time
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Embodiment 1
[0021] Embodiment 1: formula is as follows:
[0022] Sulfamethoxine 10g
[0023] Trimethoprim 2g
[0024] N-Methylpyrrolidone 10g
[0025] Polyethylene Glycol-400 20g
[0027] Disodium edetate 0.01g
[0028] Sodium metabisulfite 0.2g
[0029] Add water for injection to 100ml.
[0030] The preparation method comprises the following steps:
[0031] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 50°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;
[0032] (2) Add 40ml of water for injection into the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium pyrosulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;
[0033] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volume ...
Embodiment 2
[0035] Embodiment 2: formula is as follows:
[0036] Sulfamethoxine 13g
[0037] Trimethoprim 2.5g
[0038] N-Methylpyrrolidone 8g
[0039] Polyethylene Glycol-400 30g
[0040] Sodium hydroxide 1.2g
[0041] Disodium edetate 0.015g
[0042] Sodium metabisulfite 0.3g
[0043] Add water for injection to 100ml.
[0044] The preparation method comprises the following steps:
[0045] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 55°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;
[0046] (2) Add 30ml of water for injection into the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium pyrosulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;
[0047] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volum...
Embodiment 3
[0049] Embodiment 3: formula is as follows:
[0050] Sulfamethoxine 15g
[0051] Trimethoprim 3g
[0052] N-Methylpyrrolidone 5g
[0053] Polyethylene Glycol-400 40g
[0054] Sodium hydroxide 1.5g
[0055] Disodium edetate 0.02g
[0056] Sodium metabisulfite 0.5g
[0057] Add water for injection to 100ml.
[0058] The preparation method comprises the following steps:
[0059] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 60°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;
[0060] (2) Add 20ml of water for injection into the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium metabisulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;
[0061] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volume...
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