Application of 3,6'-disinapoyl sucrose (DISS) in preparing product for treating tristimania

Abstract

The invention discloses new medicinal application of 3,6'-disinapoyl sucrose (DISS), in particular the application of the 3,6'-disinapoyl sucrose (DISS) in preparing a product for treating tristimania. The 3,6'-disinapoyl sucrose (DISS) has better therapeutic effect on treating the tristimania caused by various reasons and obvious anti-depression activity to a pharmacological depression model, and the anti-depression activity of the 3,6'-disinapoyl sucrose is relative to the enhancement of the functions of 5-hydroxytryptamine (5-HT) and noradrenergic (NE) nerves. The DISS has no central excitation or inhibitive action within the range of an effective dosage of anti-depression.

Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to a new drug application of 3,6'-dicinapoyl sucrose (3',6-disinapoyl sucrose, DISS) extracted from natural plants and / or obtained in chemical synthesis, and specifically relates to Their application in preparing products for treating depression. technical background

[0002] Depression is the main type of affective disorder, characterized by significant and persistent low mood. In 1996, the World Health Organization (WHO) released a survey on the "Global Burden of Disease", which showed that depression had become the fourth largest disease in the world in 1990, accounting for 3.7% of the total disease burden; It is the second largest disease after ischemic heart disease, accounting for 5.7% of the total disease burden. Depression will be one of the most serious human diseases in the 21st century. The existing antidepressant western medicines mainly include tricyc...

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