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Application of 3,6'-disinapoyl sucrose (DISS) in preparing product for treating tristimania

A technology for sucrose and depression, which is applied in the field of traditional Chinese medicine and can solve the problems of high price, toxic and side effects, and poor antidepressant effect.

Inactive Publication Date: 2009-11-18
GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), they all have different degrees of toxic and side effects, and are expensive
In addition, there are still about 1 / 3 of depressed patients who do not respond well to these antidepressants in clinical use

Method used

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  • Application of 3,6'-disinapoyl sucrose (DISS) in preparing product for treating tristimania
  • Application of 3,6'-disinapoyl sucrose (DISS) in preparing product for treating tristimania
  • Application of 3,6'-disinapoyl sucrose (DISS) in preparing product for treating tristimania

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0009] Example: Pharmacodynamic evaluation of Polygala 3,6'-Dierucanoyl sucrose on drug-induced depression model

[0010] 1. Materials:

[0011] 1.1 Animals: KM mice, ♂, weighing 18-22 g, provided by the Animal Center of the Academy of Military Medical Sciences, certificate number: SCXK-(Army) 2002-001.

[0012] 1.2 Drugs and reagents Desipramine (DMI), Apomorphine (APO), Yohimbine (Yohinbin, YOH), 5-hydroxytryptophan (5-hydroxytryptophan, 5-HTP), Pagiline (pargyline), are all products of sigma company.

[0013] 1.3 Instruments and materials Fab-Ms mass spectrometer Micromass ZabSpec (USA), nuclear magnetic resonance instrument JNM-ECA-400 superconducting instrument (Japan), column chromatography silica gel (200-300 mesh) and thin-layer chromatography silica gel F254 (both Qingdao Marine chemical plant). J2298-CM animal autonomous activity monitor (developed by the Institute of Materia Medica, Chinese Academy of Medical Sciences); Polygala is the dry root of Polygala tenuif...

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Abstract

The invention discloses new medicinal application of 3,6'-disinapoyl sucrose (DISS), in particular the application of the 3,6'-disinapoyl sucrose (DISS) in preparing a product for treating tristimania. The 3,6'-disinapoyl sucrose (DISS) has better therapeutic effect on treating the tristimania caused by various reasons and obvious anti-depression activity to a pharmacological depression model, and the anti-depression activity of the 3,6'-disinapoyl sucrose is relative to the enhancement of the functions of 5-hydroxytryptamine (5-HT) and noradrenergic (NE) nerves. The DISS has no central excitation or inhibitive action within the range of an effective dosage of anti-depression.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to a new drug application of 3,6'-dicinapoyl sucrose (3',6-disinapoyl sucrose, DISS) extracted from natural plants and / or obtained in chemical synthesis, and specifically relates to Their application in preparing products for treating depression. technical background [0002] Depression is the main type of affective disorder, characterized by significant and persistent low mood. In 1996, the World Health Organization (WHO) released a survey on the "Global Burden of Disease", which showed that depression had become the fourth largest disease in the world in 1990, accounting for 3.7% of the total disease burden; It is the second largest disease after ischemic heart disease, accounting for 5.7% of the total disease burden. Depression will be one of the most serious human diseases in the 21st century. The existing antidepressant western medicines mainly include tricyc...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P25/24A23L1/30A23L33/10
Inventor 刘屏郭代红胡园穆丽华廖红波王东晓
Owner GENERAL HOSPITAL OF PLA
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