Medical composition for injection
A composition and technology for injection, applied in the field of medicine, can solve the problems of poor stability of vitamin C, failure of compound vitamin C powder injection or freeze-dried powder, etc.
Inactive Publication Date: 2010-01-13
北京普瑞博思生物科技有限公司
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Problems solved by technology
With the improvement of people's living standards, the clinical application of total parenteral nutrition is becoming more and more widespread, and the market potential is huge. Compound vitamin C injection has been on the market in Japan for several years, but vitamin C has poor stability in aqueous solution. Therefore, pharmaceutical developers hope to study Powder injections or freeze-dried powder injections replace injections, but in the process of researching powder injections or freeze-dried powder injections, the problem of stability of raw materials has also been encountered. Therefore, research on compound vitamin C powder injections or freeze-dried powders has been going on. unable to succeed
Method used
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Examples
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Embodiment 1
[0044] A pharmaceutical composition for injection, consisting of vitamin B 1 5g, 1g of riboflavin sodium phosphate (calculated as riboflavin), 100g of vitamin C, 100g of excipient, 0.1g of complexing agent, and an appropriate amount of pH regulator.
Embodiment 2
[0046] A pharmaceutical composition for injection, which is composed of vitamin B 1 20g, riboflavin sodium phosphate (calculated as riboflavin) 10g, vitamin C 300g, excipient 500g, complexing agent 1g, pH adjuster in proper amount.
Embodiment 3
[0048] A pharmaceutical composition for injection, which is composed of vitamin B 1 6g, 2g of riboflavin sodium phosphate (calculated as riboflavin), 120g of vitamin C, 150g of excipient, 0.15g of complexing agent, and an appropriate amount of pH regulator.
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The invention discloses a medical composition for injection, which is characterized by comprising the following components by weight part: 5-20 parts of vitamin B1, 1-10 parts of riboflavin sodium phosphate (metered by riboflavin), 100-300 parts of vitamin C, 100-500 parts of excipient, 0.1-1 part of complexing agent and a pH regulating agent. Compared with a vitamin C injection on the market, the medical composition has low content of related substances and high content of effective constituents; and proved by high-temperature, high-humidity and strong-light tests, the medical composition has better stability.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a compound vitamin C pharmaceutical composition for injection. Background technique [0002] The so-called "nutritional supplements" include carbohydrates, proteins, fats, vitamins, minerals and other five essential nutrients for the body. These substances bypass the liver and directly enter the body circulation. It can meet the needs of maintaining nutrition. Providing nutrients parenterally can reduce the secretion and peristalsis of the digestive tract, keep the digestive tract in a state of rest, and help the recovery or healing of diseases. Sometimes, although complete self-healing cannot be achieved, after active nutritional support, the general condition is greatly improved, which greatly increases the chance of successful further treatment and reduces the mortality rate sharply. In short bowel syndrome, it can play a role in maintaining nutrition until the intestinal tr...
Claims
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IPC IPC(8): A61K31/675A61K31/51A61K31/375A61K9/19A61K9/14A61P3/02
Inventor 郭鸿旭谢小飞张艳清
Owner 北京普瑞博思生物科技有限公司