Lornoxicam compound and purifying method thereof

Abstract

The invention discloses a lornoxicam compound and a purifying method thereof. In the method, a simple silicagel column chromatography method is used, and a proper stationary phase and a proper mobile phase are used, i.e. silicagel is used as the stationary phase and a mixed solvent of isopropanol and acetone with a certain proportion is used as the mobile phase, the temperature of the column is kept to be higher than the room temperature, and the lornoxicam can be efficiently purified. The method can achieve high yield and high purity, thereby being an effective method for obtaining the lornoxicam with high purity.

Description

technical field

[0001] The invention relates to a method for purifying a compound, in particular to a method for purifying a lornoxicam compound, and belongs to the technical field of medicines. Background technique

[0002] Lornoxicam (Lornoxicam), the chemical name is 6-chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thiophene-[2,3-e]-1,2-thiazine- 3-carbon oxalylethylenediamine-1,1-dioxide, molecular formula: C 13 h 10 ClN 3 o 4 S 2 , molecular weight: 371.82, chemical structural formula:

[0003]

[0004] Lornoxicam belongs to the non-steroidal anti-inflammatory analgesics, which is a thiazide derivative and has strong analgesic and anti-inflammatory effects. Its mechanism of action includes: 1) inhibiting the synthesis of prostaglandins by inhibiting the activity of cyclooxygenase (COX); but lornoxicam does not inhibit the activity of 5-lipid oxidase, so it does not inhibit the synthesis of leukotrienes, It also does not shunt arachidonic acid to the 5-lipid oxidase ...

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