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Drug composite containing lansoprazole and naproxen

A technology of lansoprazole and composition, applied in the field of pharmaceutical compositions containing lansoprazole and naproxen, can solve problems such as serious adverse reactions in the gastrointestinal tract

Inactive Publication Date: 2010-03-31
STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Like most NSAIDs, naproxen is very effective in relieving the inflammation and pain of arthritis, but it has serious adverse reactions in the gastrointestinal tract such as gastric ulcers

Method used

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  • Drug composite containing lansoprazole and naproxen
  • Drug composite containing lansoprazole and naproxen
  • Drug composite containing lansoprazole and naproxen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1 Lansoprazole and Naproxen tablet

[0008] prescription:

[0009]

[0010]

[0011] Preparation:

[0012] Pass lansoprazole, naproxen, microcrystalline cellulose, pregelatinized starch and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, 18-mesh Sieve for granulation, add magnesium stearate, mix evenly, and press a suitable die to form a tablet.

Embodiment 2

[0013] Embodiment 2: Lansoprazole and Naproxen capsules

[0014] prescription:

[0015]

[0016] Preparation:

[0017] Pass lansoprazole, naproxen and microcrystalline cellulose through 80-mesh sieve respectively, mix well, add 0.5% PVP-k 30 ethanol solution to make soft material, granulate with 24-mesh sieve, dry, and sieve with 24-mesh granules, add the prescribed amount of talcum powder, mix evenly, and put it into a suitable capsule shell.

Embodiment 3

[0018] Embodiment 3: Lansoprazole and Naproxen soft capsules

[0019] prescription:

[0020]

[0021]

[0022] Preparation:

[0023] First heat about 80% PEG400 to 40-60°C, add lansoprazole and naproxen, stir to dissolve, then add the prescribed amount of propylene glycol and Tween-80, stir evenly, then add the remaining amount of PEG400 to obtain Clarity solution; adjust the weight of the content, press, that is.

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PUM

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Abstract

The invention relates to a drug composite containing lansoprazole and naproxen, which takes lansoprazole and naproxen as active constituents and forms the drug composite by mixing acceptable accessories pharmaceutically; in the composite, the weight ratio of the lansoprazole and naproxen is 1;3-1:33, 1:17 is preference. The drug composite can be prepared into oral preparation and is used for treating rheumatoid arthritis, osteoarthritis and ankylosing spondylitis patients who use non-steroidal anti-inflammatory drugs to cause gastrohelcosis danger possibly.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing lansoprazole and naproxen, which belongs to the technical field of medicine. Background technique [0002] Lansoprazole is a new proton pump inhibitor. After the product enters the parietal cells from the blood, it is activated under acidic conditions and binds to the sulfhydryl group of the proton pump (H+ / K+)-ATPase, inhibiting the activity of the enzyme and thereby inhibiting acid secretion. It is commonly used in the treatment of peptic ulcer. [0003] Naproxen is a non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects, and works by inhibiting the synthesis of prostaglandins. NSAIDs are the most widely prescribed class of drugs in the world. Like most non-steroidal anti-inflammatory drugs, naproxen is very effective in relieving inflammation and pain of arthritis, but it has serious adverse reactions in the gastrointestinal tract such ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K31/192A61P29/00A61P1/04
Inventor 任洪发万响林
Owner STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
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