Oral care products comprising buffer systems for improved mineralization/remineralization benefits
A technology for oral products and chewing gum, applied in the field of oral care products and dental care, can solve problems such as loss of tooth structure, cavity formation, and enamel collapse.
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Embodiment 1
[0135] Example 1: Experimental Test
[0136] test
[0137] The purpose of this test is to evaluate the in vitro effectiveness of the combination of soluble calcium and phosphate. Testing was conducted at the University of Indiana. Enamel samples (3x3x3mm diameter windows) were taken from extracted human teeth, mounted on acrylic rods. Enamel surfaces were ground and polished with alumina slurry, rinsed with deionized water, and air-dried. The enamel specimens were then artificially injured by soaking for 96 hours in partially saturated HAP acid buffer, adjusted to pH 5, consisting of 0.1 mM lactic acid and 0.2 wt% Carbopol C907. Each specimen was subjected to a Vickers diamond with a load of 200 g for 15 seconds to make 4 baseline indentations, and the indentation length must be within the range of 25-45 μm. Enamel specimens (N=18 / treatment) were then passed through a series of solutions on a daily basis for repeated periods of 8 days. Artificial saliva, acid challenge ...
Embodiment 2
[0157] Example 2: Oral Care Product Formulation
[0158] Table 4: Chewing gum compositions
[0159] Composition (weight%)
Example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7
Gum base
33.23
30.60
31.10
35.60
35.1
34.23
31.87
Sorbitol
41.12
39.00
35.00
35.50
35.1
42.72
41.00
Calcium Citrate
6.75
7.50
10.00
8.50
4.50
*
3.34
calcium glycerophosphate
*
*
*
*
*
7.75
3.34
Encapsulated Sodium Phosphate
(47%) and phosphorus
Potassium Oxide (13%)
5.00
7.50
10.00
*
*
6.00
7.00
Encapsulated Sodium Phosphate
(35%) and phosphorus
Potassium Oxide (15%)
*
*
*
6.00
12.00
*
* ...
Embodiment 33
[0170] Example 33: Examples 30 and 31 were placed in separate mouthwash composition compartments, and when the mouthwash was administered, they were simultaneously released into the oral cavity of the consumer.
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