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Magnetic resonance elastography detection system of liver fibrosis classification research and method thereof

A magnetic resonance elasticity and imaging detection technology, which is applied in the field of liver disease detection system, can solve the problem of inability to achieve sensitivity and specificity quantitative evaluation of liver fibrosis, and achieves good image quality, obvious effect, and excellent sensitivity and specificity. Effect

Inactive Publication Date: 2010-05-19
UNIV OF SHANGHAI FOR SCI & TECH
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Problems solved by technology

[0004] Traditional magnetic resonance imaging technology cannot achieve quantitative evaluation of liver fibrosis with good sensitivity and specificity

Method used

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  • Magnetic resonance elastography detection system of liver fibrosis classification research and method thereof
  • Magnetic resonance elastography detection system of liver fibrosis classification research and method thereof
  • Magnetic resonance elastography detection system of liver fibrosis classification research and method thereof

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0022] The basic principle of nuclear magnetic resonance elastography technology is to use magnetic resonance imaging technology to detect the particle displacement of tissues in the body under the action of some external force, and obtain MRI phase images through the action of motion sensitive gradient (Motion Sensitive Gradient, MSG), based on this Through the inverse solution of elastic mechanics, the distribution map of the elastic coefficient of each point in the tissue (that is, the magnetic resonance elastogram) is obtained, and the elastic mechanical parameters of the tissue are used as the basis for grading liver fibrosis. The mathematical principle of MRE is briefly described as follows. The stable motion equation of the shear wave at the acoustic frequency in the isotropic viscoelastic medium is:

[0023] - ρ ...

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Abstract

The invention relates to magnetic resonance elastography detection system and method thereof. The detection system comprises a high-field nuclear magnetic resonance whole body imaging system which can carry out liver imaging, and a shear wave excitation device. The detection method comprises the following steps of: (1) inner particle displacement on a phantom or a detected part; (2) magnetic resonance elastography forming; and (3) fibration classification. For preliminary experiments on the phantom as well as studies on background phase noise and experiment researches on the relationship between shear wave transmission and shear wave frequency, the invention has good image quality and obvious effect. The invention establishes a foundation for subsequent MRE researches on the liver tissue, and provides directions and references for elastic researches on other parts.

Description

technical field [0001] The invention relates to a liver disease detection system and method thereof, in particular to a nuclear magnetic resonance elastography detection system capable of grading liver fibrosis and detecting liver fibrosis rate and the method thereof. Background technique [0002] The main early pathological change of various liver diseases is liver fibrosis. In theory, fibrosis can be reversed by treatment and the liver can return to normal. Once the fibrosis further develops into liver cirrhosis, it cannot be reversed. Therefore, the accurate judgment of the degree of liver fibrosis and the rate of fibrosis is crucial for the selection of corresponding treatment operations and the evaluation of treatment prognosis, which is of great clinical significance. [0003] At present, liver biopsy is the gold standard for judging liver fibrosis, but liver biopsy is an invasive test, and it is difficult for most patients to accept this method. At the same time, this...

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Application Information

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IPC IPC(8): A61B5/055G01R33/32G01R33/565
Inventor 汪红志王鹤黄清明黄勇张学龙
Owner UNIV OF SHANGHAI FOR SCI & TECH
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