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Bidens parviflora willd extractive, preparation method thereof and application in preparing medicines for resisting prostatic disorders

The technology of extract and flower ghost, which is applied to traditional Chinese medicine extract and its application field, can solve the problem of less active chemical components of Nephatanthus chinensis, and achieve the effect of inhibiting LNCaP cell secretion, less side effects, and broad application prospect.

Inactive Publication Date: 2012-06-13
深圳市药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there are few research reports on the active chemical components of P.

Method used

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  • Bidens parviflora willd extractive, preparation method thereof and application in preparing medicines for resisting prostatic disorders
  • Bidens parviflora willd extractive, preparation method thereof and application in preparing medicines for resisting prostatic disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 2.0kg of the dried whole plant of P. florida was extracted twice with 20 times the amount of chloroform for 48 hours each time. The extracts were combined, and the solvent was recovered under reduced pressure to obtain an extract, which was a yellow-red powder. Extract with a water-saturated n-butanol-ethyl acetate mixed solvent with a volume ratio of 4:1, repeat several times until the color of the extract becomes lighter, combine the solvents of the extract, and dry under reduced pressure to obtain the total flavonoids extract of P. Material 176.0g. As determined by ultraviolet-visible spectrophotometry, the total flavonoid content in the extract is 88%.

Embodiment 2

[0031] 2.0kg of the dried whole plant of P. florida was extracted twice with 20 times the amount of ethyl acetate for 48 hours each time. The extracts were combined, and the solvent was recovered under reduced pressure to obtain the extract. The extract was a yellow-red powder. Then extract with a water-saturated n-butanol-ethyl acetate mixed solvent with a volume ratio of 4:1, repeat several times until the color of the extract becomes lighter, combine the solvents of the extract, and dry under reduced pressure to obtain the total flavonoids of P. Extract 178.2g. As determined by ultraviolet-visible spectrophotometry, the total flavonoid content in the extract is 89%.

Embodiment 3

[0033] 2.0kg of the dried whole plant of P. florida was heated and refluxed twice with 20 times the amount of 60% ethanol for 1.0 hour each time. The extracts were combined, and the solvent was recovered under reduced pressure to obtain the extract. The extract was brown powder. Suspend the 60% ethanol extract in 10 times the amount of water, put it on a macroporous adsorption resin column (column bed volume 15L), and use 3 times the retained volume of water, 30% ethanol, 60% ethanol, and 95% ethanol to elute successively, The 30% ethanol, 60% ethanol and 95% ethanol eluents were combined and dried under reduced pressure to obtain 202.0 g of the total flavonoids extract of Coccinosa florida. As determined by ultraviolet-visible spectrophotometry, the total flavonoid content in the extract is 60%.

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PUM

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Abstract

The invention provides a bidens parviflora willd extractive and a preparation method and usage thereof. The bidens parviflora willd extractive comprises totally 60 to 90 percent of flavone which mainly contains rutin, hyperoside, quercetin and other flavonoid ingredients. The bidens parviflora willd extractive has the preparation method that bidens parviflora willd raw material is extracted and concentrated with chloroform, ethyl acetate or 30 to 95 percent ethanol. The invention also provides a pharmaceutical composition, which contains a pharmaceutically effective amount of bidens parviflora willd extractive and pharmaceutical excipients. The activity test result of the bidens parviflora willd extractive in resisting prostatic hypertrophy and prostate cancer shows that the bidens parviflora willd extractive is widely used in preparing medicines for resisting prostatic disorders.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extracts and applications thereof, in particular to the extracts of ghost needles and the preparation method thereof and the application of the extracts of ghost needles in the preparation of anti-prostate disease drugs. Background technique [0002] Prostatic hyperplasia is the uncontrolled non-malignant proliferation of cells in the gland. These proliferating cells often occur in the surrounding tissues surrounding the urethra. As the hyperplasia continues to increase, the gland will squeeze the urethra and block the urinary tract, resulting in bladder dysfunction. Then empty it completely, which creates an environment for infection, bladder stones and chronic prostatitis to occur. If left untreated, chronic obstruction can also cause urine to back up into the ureters, threatening kidney function. Commonly used treatment methods are drug therapy and surgical therapy. Surgical treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P13/08
Inventor 李玉兰王珏庞发根刘敏李军
Owner 深圳市药品检验所
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