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Composition for treatment of vascular dementia and preparation method thereof

A technology for vascular dementia and composition, applied in the field of pharmaceutical compositions and their preparation, can solve the problems of large adverse reactions, backward dosage forms, poor quality controllability and the like

Inactive Publication Date: 2010-08-04
SUZHOU HEALTH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine and western medicine have the disadvantages of high price and large adverse reactions in the treatment of this disease
[0008] In recent years, there have been clinical methods to treat AD with prescriptions guided by the theory of traditional Chinese medicine, and some results have been achieved. However, these prescriptions are often composed of large prescriptions, mainly decoctions, outdated dosage forms, and controllable quality. Poor performance, inconvenient to use

Method used

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  • Composition for treatment of vascular dementia and preparation method thereof
  • Composition for treatment of vascular dementia and preparation method thereof
  • Composition for treatment of vascular dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Prescription: Ginseng 2105g, Ginkgo Leaf 4211g, Melaleuca 4211g, Chuanxiong 3158g, Dilong 3158g, Polygala 3158g (equivalent to 10:20:20:15:15:15).

[0106]Preparation method: take ginseng, pulverize it, add 85% ethanol with 8 times the volume of its weight, reflux and extract for 3 times, each time for 1.5 hours, filter, leave the dregs for later use, combine the extracts, recover the ethanol under reduced pressure until exhausted, add the medicinal solution An equal volume of water-saturated n-butanol was extracted for 5 times, and the n-butanol layer was taken, and the solvent was recovered under reduced pressure and dried to obtain total ginsenosides; Ginkgo biloba was taken, and 70% ethanol with 8 times the volume of its weight was added for reflux extraction 3 times, each After 1.5 hours, combine the extracts, recover the ethanol under reduced pressure, absorb the medicinal solution through a D101 macroporous adsorption resin column, elute with 50% ethanol, collect ...

Embodiment 2

[0113] Prescription: 4091g ginseng, 2045g ginkgo leaves, 2045g Melaleuca pagoda, 1023g Chuanxiong, 1023g earthworm, 1023g polygala (equivalent to 20:10:10:5:5:5).

[0114] Preparation method: with embodiment 1.

[0115] Usage: 2 times a day, 2 capsules each time

[0116] Pharmacological test: with reference to Test Example 1, the dosage of the composition of this embodiment is 3.6g crude drug / kg, and the test results are shown in the following table:

[0117] The impact of table 9 on the spatial exploration ability of model rats ( , n=12)

[0118]

[0119] The test results show that, compared with the model group, the composition group of this example can significantly improve the learning and memory ability of the rats (p<0.05).

Embodiment 3

[0121] Prescription: Ginseng 3947g, Ginkgo biloba 1974g, Melaleuca 3947g, Chuanxiong 2961g, Dilong 2961g, Polygala 2961g (equivalent to 20:10:20:15:15:15).

[0122] Preparation method: with embodiment 1.

[0123] Usage: 2 times a day, 2 capsules each time

[0124] Pharmacological test: with reference to Test Example 1, the dosage of the composition of this embodiment is 6g crude drug / kg, and the test results are shown in the following table:

[0125] The impact of table 10 on the spatial exploration ability of model rats ( , n=12)

[0126]

[0127] The test results show that, compared with the model group, the composition group of this example can significantly improve the learning and memory ability of the rats (p<0.05).

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Abstract

The invention relates to a composition capable of treating vascular dementia, which is prepared from the following raw materials in parts by weight: 10-20 parts of ginseng, 10-20 parts of ginkgo biloba, 10-20 parts of huperzia serrata, 5-15 parts of szechuan lovage rhizome, 5-15 parts of earthworm and 5-15 parts of polygala root. The composition has simplified composing prescriptions and accurate curative effect on curing vascular dementia. The invention further relates to a preparation method of the composition, which comprises the following steps: taking ginseng, grinding, and extracting ginsenoside; taking ginkgo biloba, and extracting the total flavone of ginkgo biloba; taking szechuan lovage rhizome, and extracting essential oil; and decocting the residual medicinal materials, merging decocted liquid, filtering, concentrating to condensed paste, adding the ginsenoside, the total flavone of ginkgo biloba and the essential oil of szechuan lovage rhizome, adding auxiliary materials, and preparing a pharmaceutically acceptable preparation. The method is adopted to prepare the composition so that the composition can be ensured to be used conveniently and have controllable quality.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a composition composed of traditional Chinese medicines and a preparation method thereof. Background technique [0002] Vascular dementia (Vascular Dementia, VD) refers to the acquired intelligence impairment syndrome caused by cerebral dysfunction caused by ischemic cerebrovascular disease. Aspects of mental decline or disappearance as the main performance. It is equivalent to diseases such as "forgetfulness", "good forgetfulness", "dementia", "literary idiocy" and "epilepsy" in traditional Chinese medicine. [0003] The onset age of VD is related to cerebrovascular disease, generally after 50-60 years old, and it is more common in men clinically. The production of VD has a close causal relationship with cerebral ischemia. Hypertension, heart disease, hyperlipidemia, diabetes, drinking and smoking are risk factors for its onset. Asymptomatic str...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61P25/28A61K35/64A61K35/62
Inventor 王琳
Owner SUZHOU HEALTH COLLEGE
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