Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Synthesis and application of large-grain diameter chiral stationary phase

A technology of chiral stationary phase and large particle size, which is applied in the preparation of organic compounds, the preparation of amino hydroxyl compounds, organic chemistry, etc., can solve the problems of synthesis and application that have not been discovered, and achieve the purpose of preventing high column pressure, reducing resistance, The effect of shortening the reaction time

Inactive Publication Date: 2010-08-25
王荣
View PDF7 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patents are mainly based on silica gel, and the particle size is 5 μm, but no patent application for the synthesis and application of fillers > 5 μm for chiral fillers has been found so far.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis and application of large-grain diameter chiral stationary phase
  • Synthesis and application of large-grain diameter chiral stationary phase
  • Synthesis and application of large-grain diameter chiral stationary phase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the synthesis of a large-grain diameter chiral stationary phase, wherein a synthetic method uses silica gel with the grain diameter of 40-60mum to prepare coating type and bonding type cellulosic derivative chiral stationary phases with the coating volume ratio of 18-25 percent and obtaines better chiral separation for propranolole hydrochloride enantiomers under a positive-phase condition. Because the filling aperture is large, gaps among fillings are large, reducing the resistance for a mobile phase, thereby effectively preventing the defects of high column pressure, easy blockage, shorter life and the like of a small-grain diameter chiral column and simultaneously effectively lowering the raw material expense of a silica gel matrix in the preparation of the chiral column.

Description

technical field The invention relates to the field of synthesis and application of cellulose-based chiral stationary phase, in particular to the synthesis and application of a large particle size chiral stationary phase. Background technique With the continuous deepening of enantiochemical research, people are increasingly aware of the important role of chiral compounds in medicine, pesticides and other biological functional materials. The chiral resolution of enantiomers is an effective means to obtain optically pure substances. Chiral chromatography, especially chiral high performance liquid chromatography (chiral HPLC), is a chiral resolution method that has developed rapidly in recent years. It can be used either It can be used for analysis and separation, and can also be used for preparation and separation. It has broad application prospects in the research fields of medicine, natural products and asymmetric synthesis, and has been paid more and more attention. The co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/29B01J20/30B01J20/32C08B15/06C07C217/30C07C213/10
Inventor 王荣贾正平谢华杨沛马骏武晓玉
Owner 王荣
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com