Synthesis and application of large-grain diameter chiral stationary phase

Abstract

The invention relates to the synthesis of a large-grain diameter chiral stationary phase, wherein a synthetic method uses silica gel with the grain diameter of 40-60mum to prepare coating type and bonding type cellulosic derivative chiral stationary phases with the coating volume ratio of 18-25 percent and obtaines better chiral separation for propranolole hydrochloride enantiomers under a positive-phase condition. Because the filling aperture is large, gaps among fillings are large, reducing the resistance for a mobile phase, thereby effectively preventing the defects of high column pressure, easy blockage, shorter life and the like of a small-grain diameter chiral column and simultaneously effectively lowering the raw material expense of a silica gel matrix in the preparation of the chiral column.

Description

technical field The invention relates to the field of synthesis and application of cellulose-based chiral stationary phase, in particular to the synthesis and application of a large particle size chiral stationary phase. Background technique With the continuous deepening of enantiochemical research, people are increasingly aware of the important role of chiral compounds in medicine, pesticides and other biological functional materials. The chiral resolution of enantiomers is an effective means to obtain optically pure substances. Chiral chromatography, especially chiral high performance liquid chromatography (chiral HPLC), is a chiral resolution method that has developed rapidly in recent years. It can be used either It can be used for analysis and separation, and can also be used for preparation and separation. It has broad application prospects in the research fields of medicine, natural products and asymmetric synthesis, and has been paid more and more attention. The co...

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Problems solved by technology

The above-mentioned patents are mainly based on silica gel, and the particle size is 5 μm, but no patent application for the synthesis and application of fillers > 5 μm for chiral fillers has been found so far.

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