Acyclovir molecularly imprinted polymer, preparation method and application thereof
A technology of molecular imprinting and polymers, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of low yield and difficult separation and purification, and achieve highly selective effects
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[0030] Example Preparation and Adsorption Performance Test of Acyclovir Molecularly Imprinted Polymer
[0031] 1) Preparation of Dimethacryloyl Acyclovir
[0032] Dissolve 0.1mol of acyclovir and 0.4mol of methacryloyl chloride into a mixed solution of 100mL of acetonitrile and 20mL of dimethyl sulfoxide, reflux for 2-4 hours, distill off about 50mL of acetonitrile, cool, and add 100mL of In 0.1 mol / L sodium carbonate aqueous solution, stir for 0.5 hour to obtain white solid bismethacryloyl acyclovir with a yield of 86%.
[0033] HMNR(DMSOD6): 8.16(s, 1H), 5.52(s, 2H), 5.25(s, 2H), 5.14(s, 2H), 3.96(s, 5H), 2.92(s, 4H), 1.82(s, 6H).
[0034] 2) Preparation of acyclovir molecularly imprinted polymer
[0035] Add 2mmol dimethacryloyl acyclovir, 4mmol trimethylolpropane trimethacrylate, 80mg initiator azobisisobutyronitrile to the mixed solution of 100mL acetonitrile and 20mL dimethyl sulfoxide, mix the After the liquid is sealed, ultrasonic degassing is performed for 6 minut...
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