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Acyclovir molecularly imprinted polymer, preparation method and application thereof

A molecular imprinting and polymer technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of low yield, difficult separation and purification, etc., and achieve a highly selective effect.

Inactive Publication Date: 2010-08-25
苏州凯达生物医药技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a molecularly imprinted polymer of acyclovir, which solves the problems in the prior art that the intermediate monoester precursor is difficult to separate and purify, and the yield is not high during the synthesis of valganciclovir.

Method used

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  • Acyclovir molecularly imprinted polymer, preparation method and application thereof
  • Acyclovir molecularly imprinted polymer, preparation method and application thereof
  • Acyclovir molecularly imprinted polymer, preparation method and application thereof

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Embodiment

[0030] Example Preparation and Adsorption Performance Test of Acyclovir Molecularly Imprinted Polymer

[0031] 1) Preparation of Dimethacryloyl Acyclovir

[0032] Dissolve 0.1mol of acyclovir and 0.4mol of methacryloyl chloride into a mixed solution of 100mL of acetonitrile and 20mL of dimethyl sulfoxide, reflux for 2-4 hours, distill off about 50mL of acetonitrile, cool, and add 100mL of In 0.1 mol / L sodium carbonate aqueous solution, stir for 0.5 hour to obtain white solid bismethacryloyl acyclovir with a yield of 86%.

[0033] HMNR(DMSOD6): 8.16(s, 1H), 5.52(s, 2H), 5.25(s, 2H), 5.14(s, 2H), 3.96(s, 5H), 2.92(s, 4H), 1.82(s, 6H).

[0034] 2) Preparation of acyclovir molecularly imprinted polymer

[0035] Add 2mmol dimethacryloyl acyclovir, 4mmol trimethylolpropane trimethacrylate, 80mg initiator azobisisobutyronitrile to the mixed solution of 100mL acetonitrile and 20mL dimethyl sulfoxide, mix the After the liquid is sealed, ultrasonic degassing is performed for 6 minut...

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Abstract

The invention discloses an acyclovir molecularly imprinted polymer, a preparation method and application thereof. The polymer is prepared through the following steps of: (1) dissolving bi-methyl acryloyl acyclovir into an acetonitrile and dimethylsulfoxide solution containing a cross-linking agent and an initiating agent, sealing an obtained mixed solution and then carrying out a polymerization reaction to generate a white powdered polymer, wherein the temperature of the polymerization reaction is 50-70 DEG C, and the reaction time is 12-24h; and (2) heating and extracting the white powdered polymer to remove the template molecule acyclovir, and then extracting by using pure methanol to remove water to obtain the acyclovir molecularly imprinted polymer. The acyclovir molecularly imprinted polymer can be applied to efficiently purifying valcyte intermediates.

Description

technical field [0001] The invention relates to an acyclovir molecularly imprinted polymer and a preparation method thereof. The molecularly imprinted polymer can be used for efficient purification of valganciclovir intermediates. Background technique [0002] Ganciclovir (ganciclovir) is currently one of the most effective drugs against cytomegalovirus (CMV) infection clinically. Due to poor oral bioavailability, it can only be administered by injection. Valganciclovir (valganciclovir) is a valine ester prodrug of ganciclovir, and its oral bioavailability is greatly improved. After entering the human body, it is rapidly hydrolyzed by esterase in intestinal and liver cells to release valine and ganciclovir. The former participates in normal physiological and biochemical metabolism in the body, while the latter will effectively exert its antiviral effect at sufficient concentrations. [0003] Taking ganciclovir as the starting material can synthesize valganciclovir: gancicl...

Claims

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Application Information

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IPC IPC(8): C08F222/26C08F8/00B01J20/285B01J20/30
Inventor 李飞
Owner 苏州凯达生物医药技术有限公司
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