New medical application of fructus evodiae total alkaloid

A technology of total alkaloids and Evodia rutaecarpa, which is applied in the field of new medical application of total alkaloids of Evodia rutaecarpa, can solve the problems of small side effects and achieve the effects of small toxic and side effects, good social and economic benefits, and convenient administration

Inactive Publication Date: 2010-09-15
安徽省食品药品检验研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention aims to provide an anti-hepatic fibrosis drug, and the technical problem to be solved is to sel

Method used

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  • New medical application of fructus evodiae total alkaloid
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  • New medical application of fructus evodiae total alkaloid

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] (1) Preparation of total alkaloids from Evodia rutaecarpa

[0035] Take 6 kg of crude drug Evodia rutaecarpa, extract it with acidic ethanol reflux 4 times, each time for 1.5 hours, combine the extracts, recover part of the ethanol, adjust the pH to 2, put it on a cationic resin column, collect the eluted part of 80% ethanol after washing with water, recover the ethanol, and depressurize Concentrate and dry to obtain the total alkaloids of Evodia rutaecarpa. Based on the total alkaloids, the alkaloid content is 20-60%.

[0036] (2) Animal experiments

[0037] The experimental results are as follows:

[0038] 1. The purpose of the experiment:

[0039] The volume fraction ratio is 40%CCl 4 The salad oil solution was injected into the back or under the limbs of rats to prepare a model of liver fibrosis, and to test the therapeutic effect of total alkaloids of Evodia rutaecarpa on liver fibrosis.

[0040] 2. Test drug:

[0041] Name: Total Alkaloids of Evodia Evodia ...

Embodiment 1

[0094] Total alkaloids of Evodia rutaecarpa 100mg

[0095] Starch 100mg

[0096] Appropriate amount of starch slurry (10%)

[0097] Magnesium Stearate 1%

[0098] Process:

[0099] Mix the main ingredients and auxiliary materials, granulate with 10% starch slurry, dry and granulate, add magnesium stearate, mix evenly, and tablet.

Embodiment 2

[0100] Embodiment two: 1000 pieces

[0101] Evodia Evodia Total Alkali 100g

[0102] Starch 100g

[0103] Appropriate amount of starch slurry (10%)

[0104] Magnesium Stearate 1%

[0105] The process is the same as above.

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Abstract

The invention relates to new medical application of a fructus evodiae total alkaloid, namely, the application of the fructus evodiae total alkaloid in the preparation of a medicament for preventing and treating hepatic fibrosis. The fructus evodiae total alkaloid is a general name of indole-quinoline and quinolone alkaloids extracted and separated from fructus evodiae, and the content of the total alkaloid is between 20 and 60 percent. The fructus evodiae total alkaloid shows a certain treating effect in a therapeutic action experiment on rat hepatic fibrosis induced by carbon tetrachloride and has an excellent clinical application prospect. The fructus evodiae total alkaloid has an exact anti-hepatic fibrosis function and can be combined with auxiliary materials for preparing an anti-hepatic fibrosis medicament.

Description

1. Technical field [0001] The invention relates to a medical application of active ingredients in extracted plant Chinese herbal medicines, in particular to a new medical application of total alkaloids of evodia rutaecarpa. 2. Background technology [0002] Evodia rutaecarpa (Juss.) Benth., Evodia rutaecarpa (Juss.) Benth.vat.bodinieri (Dode) Huang, Evodia rutaecarpa (Juss.) Benth.var.officinalia (Dode) Huang dry near-ripe fruit. Spicy, bitter, hot in nature, slightly poisonous. Return liver, spleen, stomach, kidney channel. It has the effects of warming the liver and stomach, dispelling cold and relieving pain, reducing adverse effects, and drying dampness. Distributed in Anhui, Zhejiang, Fujian, Hunan, Hubei, Guangdong, Guangxi, Yunnan, Guizhou and other provinces. [0003] At present, more than 100 compounds have been isolated from the fruit of Evodia rutaecarpa, including alkaloids, bitters, volatile oils, amino acids, etc. (1) Alkaloid: It is the main active ingred...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/16
Inventor 张毅杨冬梅李莉陈师农马玲钱利武
Owner 安徽省食品药品检验研究院
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