The invention discloses an externally-applied medicament for radical treatment of all types of cancers and difficult and complicated diseases. The treatment on the difficult and complicated diseases such as cancer and the like by using the externally-applied medicament overturns the traditional treatment modes such as oral administration, operation, chemotherapy and the like, and the externally-applied medicament is externally applied to skin acupuncture points to ensure that the components of the medicament osmoses into a body to eliminate tumors and radically treat the cancer. The medicament mainly comprises the following components: Chinese eaglewood, musk, short-pedicel aconite root, broken immortality peach, clematis root, garden balsam seed, common camptotheca fruit, rubixanthin, borax, centipede, pig bile, common selfheal fruit-spike, glaucescent fissistigma root, dragon bone, olive nut, abrus cantoniensis, decumbent bugle herb and the like. Practices prove that the externally-applied medicament has no side effect in the process of treating cancer and tumor, and the cancers and tumor cannot relapse and transfer; and compared with the traditional therapeutic method, an operation is not needed, oral administration is not needed, injection is not needed, chemotherapy is also needed, and correspondingly, the mental pressure of a patient is alleviated.