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Application of plantamajoside in preparation of anti-myocardial hypertrophy drugs

A technology for myocardial hypertrophy and psyllogen, applied in drug combinations, pharmaceutical formulas, cardiovascular diseases, etc.

Active Publication Date: 2018-11-27
GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether psyllogen has an inhibitory effect on myocardial hypertrophy is still rarely reported at home and abroad.

Method used

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  • Application of plantamajoside in preparation of anti-myocardial hypertrophy drugs
  • Application of plantamajoside in preparation of anti-myocardial hypertrophy drugs
  • Application of plantamajoside in preparation of anti-myocardial hypertrophy drugs

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Experimental program
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Effect test

Embodiment Construction

[0018] The present invention establishes a model of isoproterenol-induced myocardial hypertrophy and H9c2 cardiomyocyte hypertrophy in mice, and at the same time gives psyllogen for intervention. Detect the changes in the ratio of heart weight to body weight, left ventricle weight to body weight, and heart weight to tibial length in mouse experiments, and use experimental ultrasound equipment to detect changes in cardiac function; measure the surface area of ​​H9c2 cardiomyocytes in cell experiments change. The results show that psyllogen has significant anti-cardiac hypertrophy effect, so it can be used in the research and development of anti-cardiac hypertrophy drugs.

[0019] The present invention is illustrated by the following experiments:

[0020] Experiment 1: Great psyllogen against isoproterenol-induced myocardial hypertrophy in mice.

[0021] The myocardial hypertrophy model in mice was established by continuous subcutaneous injection of isoproterenol at a concentr...

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Abstract

The invention belongs to novel application of plantamajoside in resistance of myocardial hypertrophy and particularly relates to application of plantamajoside in preparation of anti-myocardial hypertrophy drugs. An isoproterenol is adopted for inducing a myocardial hypertrophy model of a mouse and an H9c2 cardiomyocyte hypertrophy model, and meanwhile, intervention is carried out on plantamajosidedifferent in concentration; cardiac functions of the mouse are evaluated through ultrasound, the heart of the mouse and the left ventricular are weighed, and the myocardial hypertrophy degree of themouse is evaluated. The area of H9c2 cardiomyocytes is observed by means of fluorescence staining, and results show that plantamajoside has a protection effect on isoproterenol-induced myocardial hypertrophy of the mouse and an inhibitory effect on isoproterenol-induced H9c2 cardiomyocyte hypertrophy. Plantamajoside is expected to be developed for clinical use in the anti-myocardial hypertrophy drugs.

Description

[0001] Technical field: The present invention belongs to the new application of psyllogen in anti-myocardial hypertrophy, and specifically relates to the application of psyllogen in the preparation of anti-myocardial hypertrophy drugs. Background technique: [0002] With the development of society and economy, the lifestyle of Chinese residents has undergone profound changes, especially the aging population and the acceleration of urbanization, the prevalence of cardiovascular disease risk factors is very obvious, and the incidence of cardiovascular disease is increasing. Cardiac hypertrophy is one of the compensatory functions of the heart. The characteristics of hypertrophy are mainly the enlargement of cardiomyocytes, the increase of protein synthesis, the thickening of muscle fibers and the re-expression of "embryonic" genes. Sustained cardiac hypertrophy It will eventually lead to dilated cardiomyopathy, heart failure and sudden death, and is one of the independent risk fa...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P9/00
CPCA61K31/7032A61P9/00
Inventor 侯明晓赵庆春柳云恩尚琳琳吕品朱珊珊
Owner GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
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