New application of thio-taxane derivatives

Abstract

The invention discloses a new application of thio-taxane derivatives which have the structure shown in formula (1), wherein R is hydrogen, C1-18 are alkyl groups, C1-18 are substituted alkyl groups, C2-10 are alkenyl groups, C2-10 are alkynyl, C3-6 are naphthenic base, C4-6 are cyclenes base, aryl, substituted aryl, heterocyclic groups or substituted heterocyclic groups, and the substituent is one or several types selected from C1-8 alkyl groups, C1-8 alkoxy, C1-8 halogenated alkyl, halogen, aryl, nitryl or amino. The thio-taxane derivative can be used for preparing medicines for treating hepatitis B.

Description

technical field The invention belongs to the technical field of medicinal chemistry and medicine, and specifically relates to the use of a thiotaxane derivative. Background technique According to the World Health Organization, there are currently more than 300 million people suffering from hepatitis B worldwide, and 25% of them are facing the threat of liver cirrhosis and liver cancer. my country is a high-incidence area of ​​hepatitis B virus infection, the carrier rate of hepatitis B surface antigen (HBsAg) is 10%, and there are about 30 million chronic hepatitis B patients. The condition of such patients is protracted, and some may develop into liver cirrhosis and liver cancer, which is extremely harmful to human health. Big. Inoculation of hepatitis B vaccine to prevent hepatitis B is the most effective measure, but once the disease occurs, it must be actively treated. The currently domestically recognized therapy for the treatment of hepatitis B is comprehensive treat...

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