Traditional Chinese medicine extract for treating hepatitis B, and preparation method and application thereof

A hepatitis B, extract technology, applied in the field of medicine, to achieve a good dose-dependent relationship, the effect of reducing hepatic steatosis

Inactive Publication Date: 2014-03-12
JINAN XINLU MEDICAL TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that the active ingredi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine extract for treating hepatitis B, and preparation method and application thereof
  • Traditional Chinese medicine extract for treating hepatitis B, and preparation method and application thereof
  • Traditional Chinese medicine extract for treating hepatitis B, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Take 50kg of neem bark, heat and reflux with 400L deionized water to extract 3 times, the extraction time is 2, 2, and 1 hour respectively, the water extracts are combined, filtered, concentrated under reduced pressure at 60°C to a relative density of 1.05, and added to the concentrated solution Ethanol, until the ethanol concentration is 80%, precipitate overnight, filter, the filtrates are combined, the solvent is recovered under reduced pressure to a concentration of about 2.0g crude drug / ml, filter, the macroporous adsorption resin column HZ816 on the filtrate, the resin consumption is 50kg, control The flow rate is 0.2~0.5 times the column volume / h, successively eluted with 200L deionized water, 150L 10% ethanol to remove impurities, and then eluted with 150L 70% ethanol, collected the alcohol eluate, concentrated under reduced pressure, dried in vacuum, and pulverized , to obtain neem extract 240g, the total phenolic compound content is 52%, and the neem phenolic c...

Embodiment 2

[0079] Take 15 kg of Toosendan, heat and reflux with 90L deionized water to extract 3 times, the extraction time is 2, 2, and 1.5 hours respectively, the water extracts are combined, filtered, and concentrated under reduced pressure at 60 ° C to a relative density of 1.05; Add ethanol until the ethanol concentration is 90%, precipitate overnight, filter, combine the filtrates, recover the solvent under reduced pressure to a concentration of about 2.0g crude drug / ml, filter, put the filtrate on the resin column HP10, the resin consumption is 15kg, and the control flow rate is 0.2~0.5 times of column volume / h, eluted with 30L deionized water, 30L 10% ethanol to remove impurities, and then eluted with 40L 80% ethanol, collected the alcohol eluate, concentrated under reduced pressure, dried in vacuum, and pulverized to obtain Neem extract 80g, the total phenolic compound content is 53%, and the neem phenolic compound content is 21.7%.

Embodiment 3

[0081] Take 150kg of Neem leaves, heat and reflux with 900L 80% ethanol to extract twice, the extraction time is 3 and 2 hours respectively, the ethanol extracts are combined, filtered, concentrated under reduced pressure at 60°C, and the solvent is recovered to a concentration of about 2.0g crude drug / ml, filtered, and the filtrate was put on a macroporous adsorption resin column HZ801, the amount of resin was 120kg, the flow rate was controlled to be 0.2~0.5 times column volume / h, eluted with 300L deionized water and 250L 10% ethanol successively to remove impurities, and then used Eluted with 250L 60% ethanol, collected the ethanol eluent, concentrated under reduced pressure, dried in vacuum, and pulverized to obtain 906g of neem extract, with a total phenolic compound content of 57% and neem phenolic compound content of 24.5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an extract of the traditional Chinese medicine chinaberry for treating hepatitis B and a preparing method and application thereof. The traditional Chinese medicine chinaberry extract comprises more than 50% of total phenolic compounds and more than 20% of chinaberry phenolic compounds. The preparation method for the traditional Chinese medicine chinaberry extract comprises the following steps: subjecting a chinaberry raw material to hot extraction or cold extraction so as to obtain a crude chinaberry extract; and then carrying out purification by using a methacrylic synthetic adsorbent, an aromatic (styrene and didivinyl benzene) synthetic adsorbent or a gel synthetic absorbent so as to obtain the traditional Chinese medicine chinaberry extract. The invention also discloses application of the traditional Chinese medicine extract in preparation of medicines used for treating hepatitis B.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine neem extract for treating hepatitis B and its preparation method and application. Background technique [0002] Viral diseases seriously endanger people's life and health and are the main infectious diseases of human beings. The spread is extremely wide, the incidence rate is high, and there are many kinds of viruses, which multiply in cells and can infect different tissue cells to cause diseases. According to incomplete statistics, viral diseases account for 60-65% of human infectious diseases. According to the type of onset, it can be divided into: 1) acute epidemic diseases, such as influenza, acute hepatitis caused by hepatitis A or E virus, viral encephalitis caused by Japanese encephalitis virus, etc.; 2) chronic infectious diseases, such as AIDS, B, Hepatitis C patients who carry the virus for a long time can cause liver cirrhosis and live...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/58A61P1/16A61P31/20
Inventor 昌军金琳王定新
Owner JINAN XINLU MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap