The invention belongs to the technical field of medicinal chemistry, and relates to a novel matrix metal protease inhibitor and medicinal use thereof. The inhibitor is benzamide ilomastat derivative as shown in a formula (1) defined in the description, wherein R1 includes but is not limited to 2-NH2, an amino group is substituted with an acetyl amino group, R2 includes but is not limited to aromatic groups such as hydrogen atoms, fluorine, chlorine, bromine, a methyl group, an ethyl group, NH2, substituted amino, a methoxyl group, an ethoxy group, a trifluoromethyl group, a cyclohexyl group, a phenyl group, substituted phenyl, thiophene, pyrrole, furan, thiazole and pyridine, and the substituted phenyl of R2 includes but is not limited to radical groups such as a methyl group, an ethyl group, a methoxyl group, an ethoxy group, a trifluoromethyl group, a hydroxyl group, fluorine, chlorine, bromine, an acetyl group and benzophenone connected with 4' position of a benzene ring. Experiments show that the benzamide ilomastat derivative can be used for preparing drugs for resisting invasion and diffusion of tumors such as a liver cancer, a lung cancer, a breast cancer and an ovarian cancer.