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Process for isolating iodixanol from an aqueous solution

A technology of aqueous solution and triiodophenyl, applied in the field of separating iodixanol from aqueous solution, can solve problems such as low density

Inactive Publication Date: 2011-02-02
GE HEALTHCARE AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method results in powders of very low density, requiring large warehouse areas to store raw material prior to formulation

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0027] A 5400 liter aqueous solution containing about 2770 kg iodixanol was fed into the spray granulator at 30°C. The granulation throughput was about 400 kg / hour, giving a total drying time of about 7 hours. The particles have a bulk density of about 0.8-1.0 kg / L and a particle size of 20-1500 μm with a maximum particle size of about 200-300 μm. The product temperature during granulation was between 55 and 80°C. The water content in the granules was about 2 w / w%. The content of crystalline material in the dry solid is less than 0.1 w / w%, while the content of free inorganic iodide is typically not more than 2 μg / g.

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Abstract

This invention relates to the isolation of iodixanol (1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the isolation of iodixanol from an aqueous solution.

Description

[0001] Cross-references to related applications [0002] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 61 / 227,105, filed July 21, 2009, the entire disclosure of which is incorporated herein by reference. technical field [0003] The present invention relates to iodixanol (1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4, 6-triiodophenyl]-2-hydroxypropane), more specifically to the separation of iodixanol from aqueous solutions. Background of the invention [0004] Iodixanol is traded under the trade name Visipaque TM The non-proprietory name of a chemical drug that is marketed as a non-ionic X-ray contrast agent. Visipaque TM It is one of the most commonly used diagnostic agents in diagnostic X-ray methods and has been produced in large quantities. [0005] The production of such non-ionic X-ray contrast agents involves the production of chemicals (known as primary production) which are subsequentl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C237/46
CPCC07C231/24C07C237/46
Inventor A·阿斯基尔德森
Owner GE HEALTHCARE AS
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