Process for isolating iodixanol from an aqueous solution

A technology of aqueous solution and triiodophenyl, applied in the field of separating iodixanol from aqueous solution, can solve problems such as low density

Inactive Publication Date: 2011-02-02
GE HEALTHCARE AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method results in powders of very low density, requiring large warehouse areas to store raw material prior to formulation

Method used

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Examples

Experimental program
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Embodiment 1

[0027] A 5400 liter aqueous solution containing about 2770 kg iodixanol was fed into the spray granulator at 30°C. The granulation throughput was about 400 kg / hour, giving a total drying time of about 7 hours. The particles have a bulk density of about 0.8-1.0 kg / L and a particle size of 20-1500 μm with a maximum particle size of about 200-300 μm. The product temperature during granulation was between 55 and 80°C. The water content in the granules was about 2 w / w%. The content of crystalline material in the dry solid is less than 0.1 w / w%, while the content of free inorganic iodide is typically not more than 2 μg / g.

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Abstract

This invention relates to the isolation of iodixanol (1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the isolation of iodixanol from an aqueous solution.

Description

[0001] Cross-references to related applications [0002] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 61 / 227,105, filed July 21, 2009, the entire disclosure of which is incorporated herein by reference. technical field [0003] The present invention relates to iodixanol (1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4, 6-triiodophenyl]-2-hydroxypropane), more specifically to the separation of iodixanol from aqueous solutions. Background of the invention [0004] Iodixanol is traded under the trade name Visipaque TM The non-proprietory name of a chemical drug that is marketed as a non-ionic X-ray contrast agent. Visipaque TM It is one of the most commonly used diagnostic agents in diagnostic X-ray methods and has been produced in large quantities. [0005] The production of such non-ionic X-ray contrast agents involves the production of chemicals (known as primary production) which are subsequentl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C237/46
CPCC07C231/24C07C237/46
Inventor A·阿斯基尔德森
Owner GE HEALTHCARE AS
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