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Composition of aiphenyl hepatanone compound and its use

A technology of diphenylheptanone and diphenylheptanone, applied in pharmaceutical applications, in the field of pharmaceuticals, to achieve good anti-helicobacter pylori effect

Inactive Publication Date: 2009-08-26
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, so far, there is no information about diarylheptanoids (such as: diphenylheptanone, diphenylheptenone and diphenylheptanone) against Helicobacter pylori infection or treatment of intestinal, Reports on Gastric Ulcer-Related Diseases

Method used

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  • Composition of aiphenyl hepatanone compound and its use
  • Composition of aiphenyl hepatanone compound and its use
  • Composition of aiphenyl hepatanone compound and its use

Examples

Experimental program
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Effect test

Embodiment Construction

[0078] The pharmaceutical composition of the diphenylheptanone compound of the present invention is prepared by a general preparation method of pharmaceutical tablets, granules, capsules and oral liquid preparations. The proportioning contents of the compositions of the following examples are all in weight percent.

[0079] Pharmaceutical Tablets (3.9%) : Select the following amount of diphenylheptanone compounds and additives to mix evenly, use 10% pregelatinized starch slurry as a binder, wet granulate, dry, add an appropriate amount of magnesium stearate to mix, and press into tablets . 7.5 g of 5-hydroxy-1,7-diphenyl-3-heptanone (compound 1); 120 g of hydroxypropyl cellulose; 30 g of micronized silica gel; 20 g of pregelatinized starch; appropriate amount of magnesium stearate; made into 1000 tablets.

[0080] Pharmaceutical Tablets (9.7%) 18g of 5-hydroxyl-1,7-diphenyl-3-heptanone (compound 1); 120g of hydroxypropyl cellulose; 30g of micropowdered silica gel; 20g of p...

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Abstract

The present invention provides diarylheptanoids (diarylheptanoids) compounds (such as: diphenylheptanone, diphenylheptenone and diphenylheptanedione) and their pharmaceutical composition in the anti-helicobacter pylori infection or treatment of intestinal , New uses in gastric ulcer-related diseases. They have good anti-helicobacter pylori (Hp) effect, and have repairing effect on gastric mucosa damage caused by helicobacter pylori.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical application, in particular to the application of diarylheptanoids (diarylheptanoids) compounds (such as: diphenylheptanone, diphenylheptenone and diphenylheptanone) and their pharmaceutical compositions , especially for use in the pharmaceutical field. Background technique [0002] Chronic active gastritis, gastric ulcer and duodenal ulcer, gastric MALT lymphoma and gastric cancer are diseases that seriously endanger human health and life. Medical research has confirmed that the above diseases are all related to Helicobacter pylori (Hp) infection. Statistics show that more than 50% of the world's population is infected with Helicobacter pylori, and the infection is particularly serious in developing countries, reaching 60-80% among adults. In 1994, the International Agency for Research on Cancer (IARC) listed Hp as a Class I human carcinogen. At present, anti-endocrine drugs and antibioti...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P31/04A61P1/04C07C49/215C07C49/245
CPCC07C49/245C07C49/215A61P1/04A61P31/04
Inventor 岳建民廖志新杨升平樊成奇董蕾吴艳
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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