Growth-enhancing yeast hydrolysate and health food comprising the same

Abstract

Disclosed is a yeast hydrolyzate that increases the length and weight of bones such as the epiphysis, tibia, and femur to promote the secretion of growth hormone. One aspect of the present invention discloses a yeast hydrolyzate obtained through a process characterized by the following content, the process comprising adding 0.1 to 0.3% (w / v) proteolytic enzymes to yeast or yeast autolysate for hydrolysis Steps of treating and separating 10,000-30,000 Dalton molecular weight substances from the supernatant of the yeast hydrolyzate. Ingesting this yeast hydrolyzate is safe and has no side effects.

Description

technical field

[0001] The invention relates to a yeast hydrolyzate with a growth-promoting effect and a functional food containing the yeast hydrolyzate. Background technique

[0002] Growth refers to the increase in height, which can be promoted by nutrients and growth hormones. In particular, the nervous system, which includes the pituitary gland, which secretes growth hormone, develops rapidly during infancy and then gradually slows down.

[0003] Longitudinal growth of long bones determines human height and bone structure, and this growth is controlled by specialized structures. In particular, the growth of the epiphyseal growth plate (epiphyseal growth plate) used in the tibia plays a very important role in the longitudinal growth process of the bone (Dongzhi Yang et al., 2003). The growth plate is divided into a proliferation zone where chondrocytes proliferate, a maturation zone and a hyertrophic zone where chondrocytes mature and enlarge. The interaction of the t...

Examples

Embodiment 1

[0059] Example 1: Production of Yeast Hydrolyzate

[0060] Suspend 8g of compressed yeast in 100ml of distilled water, and adjust the pH to 6-8, then add 1.0% protease (flavored protease, Novozymes (Korea) Co., Ltd., 1000LAPU / g), and at a temperature of 50°C Hydrolysis treatment under ambient conditions for 48 hours. After it was subjected to centrifugation, ultrafiltration membranes (PM-10&-30) were used to collect the part with a molecular weight of 10,000 to 30,000 in the supernatant and dried to produce a yeast breakdown product for subsequent experiments.

Embodiment 2

[0061] Embodiment 2: animal test

[0062] experimental animals

[0063] 3-year-old male rats of the Sprague-Dawley line for the test were purchased from the Center for Experimental Animals (Seoul), and stored in stainless steel cages, and 2 rats were stored in each stainless steel cage. Under 23 ± 1 ℃ of temperature and 60% humidity environment, after raising in advance 3 days with solid feed (manufactured by Sanyang Feed Co., Ltd.), adopt random block design method to be divided into four comparison groups, for example: negative contrast group (N- control), the positive control group (P-control) who ingested 1g / kg of colostrum orally per day, and the YH-1 and YH-2 groups who ingested 0.5g / kg and 1.0g / kg of yeast hydrolyzate, respectively, The test period is 4 weeks. Each group consisted of 8 rats.

[0064] Free intake of AIN-93 standard feed. The average daily feed intake was obtained from the total feed intake on a weekly basis, and the feed intake during the test period...

technical field

[0001] The invention relates to a yeast hydrolyzate with a growth-promoting effect and a functional food containing the yeast hydrolyzate. Background technique

[0002] Growth refers to the increase in height, which can be promoted by nutrients and growth hormones. In particular, the nervous system, which includes the pituitary gland, which secretes growth hormone, develops rapidly during infancy and then gradually slows down.

[0003] Longitudinal growth of long bones determines human height and bone structure, and this growth is controlled by specialized structures. In particular, the growth of the epiphyseal growth plate (epiphyseal growth plate) used in the tibia plays a very important role in the longitudinal growth process of the bone (Dongzhi Yang et al., 2003). The growth plate is divided into a proliferation zone where chondrocytes proliferate, a maturation zone and a hyertrophic zone where chondrocytes mature and enlarge. The interaction of the t...

Examples

Embodiment 1

[0059] Example 1: Production of Yeast Hydrolyzate

[0060] Suspend 8g of compressed yeast in 100ml of distilled water, and adjust the pH to 6-8, then add 1.0% protease (flavored protease, Novozymes (Korea) Co., Ltd., 1000LAPU / g), and at a temperature of 50°C Hydrolysis treatment under ambient conditions for 48 hours. After it was subjected to centrifugation, ultrafiltration membranes (PM-10&-30) were used to collect the part with a molecular weight of 10,000 to 30,000 in the supernatant and dried to produce a yeast breakdown product for subsequent experiments.

Embodiment 2

[0061] Embodiment 2: animal test

[0062] experimental animals

[0063] 3-year-old male rats of the Sprague-Dawley line for the test were purchased from the Center for Experimental Animals (Seoul), and stored in stainless steel cages, and 2 rats were stored in each stainless steel cage. Under 23 ± 1 ℃ of temperature and 60% humidity environment, after raising in advance 3 days with solid feed (manufactured by Sanyang Feed Co., Ltd.), adopt random block design method to be divided into four comparison groups, for example: negative contrast group (N- control), the positive control group (P-control) who ingested 1g / kg of colostrum orally per day, and the YH-1 and YH-2 groups who ingested 0.5g / kg and 1.0g / kg of yeast hydrolyzate, respectively, The test period is 4 weeks. Each group consisted of 8 rats.

[0064] Free intake of AIN-93 standard feed. The average daily feed intake was obtained from the total feed intake on a weekly basis, and the feed intake during the test period...

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