Weight-reducing and lipid-lowering composition

A composition and lipid-lowering technology, applied in the field of medicine, can solve the problems of high cost of drug treatment, difficulty in adherence to patients, and easy rebound, etc., and achieve the effects of good thermodynamic and kinetic stability, improved efficacy, and increased water solubility

Inactive Publication Date: 2012-02-29
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, besides acupuncture, there are mainly behavioral therapy, diet therapy, exercise therapy, drug therapy and surgical therapy in the clinical treatment of obesity. Although there are many methods, behavioral, diet and exercise therapy are generally difficult for patients to adhere to, and drug treatment is expensive. Surgery has certain risks, and the above methods are prone to rebound

Method used

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  • Weight-reducing and lipid-lowering composition
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  • Weight-reducing and lipid-lowering composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 A kind of fat-reducing composition for weight loss and its preparation

[0027] 1. A weight-reducing and lipid-lowering composition, which is made of the following raw materials in parts by weight: 50 g of curcumin and 80 g of chitosan, wherein the molecular weight of chitosan is 100 kDa, and the degree of deacetylation is 90%.

[0028] Dissolve 1 g of the above composition in 100 ml of 1% hydrochloric acid aqueous solution, then stir magnetically for 30 to 40 minutes, and filter through a filter membrane with a pore size of 0.2 micron to obtain the composition solution. Curcumin content 0.38g (C-18 reverse-phase column, acetonitrile: 4% glacial acetic acid=48: 52 is mobile phase, detection wavelength is 430nm) in liquid chromatography determination solution, good stability.

[0029] 2. Preparation of a fat-reducing composition for weight loss: take 80g of chitosan, slowly add 50g of curcumin under stirring, add 50g of lactose, add 8g of lubricant magnesium...

Embodiment 2

[0030] Embodiment 2 A kind of fat-reducing composition for weight loss and its preparation

[0031] 1. A weight-reducing and lipid-lowering composition, which is made of the following raw materials in parts by weight: 20 g of curcumin, 50 g of chitosan, wherein the molecular weight of chitosan is 600 kDa, and the degree of deacetylation is 92%.

[0032] Dissolve 1 g of the above composition in 100 ml of 1% hydrochloric acid aqueous solution, then stir magnetically for 30 to 40 minutes, and filter through a filter membrane with a pore size of 0.2 micron to obtain the composition solution. Curcumin content 0.27g (C-18 reverse-phase column, acetonitrile: 4% glacial acetic acid=48: 52 is mobile phase, detection wavelength is 430nm) in liquid chromatography determination solution, good stability.

[0033] 2. Preparation of a fat-reducing composition for weight loss: take 50 g of chitosan, slowly add 20 g of curcumin under stirring, add 20 g of carrier lactose or 20 g of cornstarch,...

Embodiment 3

[0034] Embodiment 3 A kind of fat-reducing composition for weight loss and its preparation

[0035] 1. A fat-reducing composition for weight loss, which is made of the following raw materials in parts by weight: curcumin 40g, chitosan 70g, hydroxycitric acid 10g, L-malic acid 10g, carnitine tartrate 2g, wherein chitosan The molecular weight of sugar is 600kDa, and the degree of deacetylation is 90%.

[0036]Dissolve 1 g of the above composition in 100 ml of 1% hydrochloric acid aqueous solution, then stir magnetically for 30 to 40 minutes, and filter through a filter membrane with a pore size of 0.2 micron to obtain the composition solution. Curcumin content 0.35g (C-18 reverse-phase column, acetonitrile: 4% glacial acetic acid=48: 52 is mobile phase, detection wavelength is 430nm) in liquid chromatography determination solution, good stability.

[0037] 2. Preparation of a fat-reducing composition for weight loss: Take 70g of chitosan, slowly add 40g of curcumin, 10g of hydr...

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Abstract

The invention discloses a weight-reducing and lipid-lowering composition which comprises 20-50 parts of curcumin and 50-80 parts of chitosan, and one or more of 10-30 parts of hydroxycitric acid, L-malic acid or carnitine tartrate can be added to the curcumin and the chitosan. Experimental results indicate that the weight-reducing and lipid-lowering composition provided by the invention has scientific and reasonable proportioning, and the curcumin can be effectively immobilized by the chitosan to enhance the water solubility of the curcumin; the experimental results indicate that the composition of the curcumin and the chitosan has good chemical stability and high bioavailability; and the experimental results indicate that the curcumin can be compatible with the chitosan to perform cooperative and synergistic actions and markedly improve the weight-reducing and lipid-lowering effects, so that the composition can be developed into a new weight-reducing and lipid-lowering medicament or healthcare food.

Description

technical field [0001] The invention relates to a medicine, in particular to a weight-reducing and lipid-lowering composition and its application. Background technique [0002] Curcumin is a pigment extracted from turmeric, a plant of the ginger family, and is also present in other plants of the ginger family. Modern studies have found that curcumin can inhibit inflammation, anti-oxidation, and anti-rheumatoid. American VITY vitamin magazine reported: "The main pharmacological effects of curcumin include anti-oxidation, anti-inflammation, anti-coagulation, lipid-lowering, anti-atherosclerosis, anti-aging, eliminating free radicals and inhibiting tumor growth." In November 2006, the United States " An article in the journal Arthritis and Rheumatism pointed out that curcumin can prevent joint swelling and arthritis, and is effective for cardiovascular diseases and cancer, and medical research has shown that curcumin has the effects of lowering blood fat, promoting choleresis,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K31/12A61P3/04A61P3/06A61K31/194A61K31/205A23L1/09A23L33/105A23L33/125
Inventor 王令充孙永
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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