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Pharmaceutical composition compounded with compound liposoluble vitamins and preparation method thereof

A technology of vitamins and sterilization methods, which is applied in the directions of drug combinations, pharmaceutical formulations, and inactive medical preparations, etc., can solve the problems such as the decrease in the content of complex fat-soluble vitamins, and achieve the effect of ensuring safety.

Active Publication Date: 2010-12-22
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that the content of complex fat-soluble vitamins drops sharply after sterilization

Method used

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  • Pharmaceutical composition compounded with compound liposoluble vitamins and preparation method thereof
  • Pharmaceutical composition compounded with compound liposoluble vitamins and preparation method thereof
  • Pharmaceutical composition compounded with compound liposoluble vitamins and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the preparation of injection

[0059] Take 100ml of water for injection, 0.05g of calcium sodium edetate and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin and stir to disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

Embodiment 2

[0060] Embodiment 2: the preparation of injection

[0061] Take 100ml of water for injection, 0.025g of calcium sodium edetate and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin and stir to disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

Embodiment 3

[0062] Embodiment 3: the preparation of injection

[0063] Take 100ml of water for injection, 0.001g of calcium sodium ethylenediaminetetraacetic acid and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin, stir and disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

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Abstract

The invention relates to a pharmaceutical composition of compound liposoluble vitamins, comprising vitamin A, vitamin D2, vitamin E, vitamin K1 and a metal ion chelant (such as edetate). The pharmaceutical composition can be made into an injection emulsion, preferably solve the problem that degradation products are generated because the active constituents ( such as the vitamin D2 and the vitamin K1) are oxidized in the preparation and sterilization processes, and ensure the safety of clinical administration.

Description

[0001] The present invention is a divisional application, the original application number is 200710120305.6, the original application date is August 15, 2007, and the original application name is a pharmaceutical composition of complex fat-soluble vitamins and its preparation method. field of invention [0002] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a fat-soluble vitamin pharmaceutical composition and a preparation method thereof. Background technique [0003] Fat-soluble vitamins are one of the indispensable components of parenteral nutrition to meet the daily requirements of fat-soluble vitamin A and vitamin D for adults. 2 , vitamin E, vitamin K 1 physiological needs. Fat-soluble vitamin injections were prepared according to the prescription amount, and vitamin A, vitamin E, and vitamin D were used for fat-soluble vitamin injections before and after sterilization. 2 and vitamin K 1 Assays were carried ou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K47/18A61P3/02
Inventor 王利春孔繁贵胡思玉余启波罗琴张德奎梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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