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Ergosterol preparation method

A technology for ergosterol and ethanol, applied in directions such as steroids, organic chemistry, etc., can solve the problems of loss of consciousness, inflammability and explosion, low yield of light ethanol extraction, etc., and achieves the effects of simple production process and low production cost.

Active Publication Date: 2006-05-03
SICHUAN NEIJIANG HUIXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of using this method is that the extraction yield with light ethanol is low; ether is highly toxic, can cause people to lose consciousness or even die, and is flammable and explosive; low temperature conditions of -5°C increase the cost, so this method is difficult to realize industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Saponification

[0020] Take 115kg of sodium hydroxide liquid (containing NaOH35%) and 10kg of sodium chloride, put them into a saponification pot, add 100kg of dry yeast powder under stirring, saponification temperature is 100°C, and saponification reaction is 12h;

[0021] (2) extraction

[0022] Get 337kg of toluene, add in the saponification liquid and carry out extraction, the extraction temperature is 60 ℃;

[0023] (3) washing

[0024] The toluene feed liquid after the extraction is washed with water to make the toluene feed liquid clear and transparent;

[0025] (4) concentrated

[0026] Put the toluene feed liquid into the concentration pot to concentrate, then add ethanol to dissolve, and stand to crystallize to obtain the crude ergosterol;

[0027] (5) refined

[0028] The crude product of ergosterol was dissolved in a mixed solvent of toluene and ethanol (1:2), then filtered through activated carbon, and vacuum-dried to obtain the finished product o...

Embodiment 2

[0030] (1) Get 200kg of sodium hydroxide liquid (containing NaOH35%), 30kg of sodium chloride, put it in the saponification pot, add dry yeast powder 100kg under stirring, saponification temperature 105 ℃, saponification reaction 12h;

[0031] (2) Get toluene 396kg, add in saponification liquid and carry out extraction, extraction temperature is 80 ℃;

[0032] (3) washing

[0033] The toluene feed liquid after the extraction is washed with water to make the toluene feed liquid clear and transparent;

[0034] (4) concentrated

[0035] Put the toluene feed liquid into the concentration pot to concentrate, then add ethanol to dissolve, and stand to crystallize to obtain the crude ergosterol;

[0036] (5) refined

[0037] The crude product of ergosterol was dissolved in a mixed solvent of toluene and ethanol (1:2), then filtered through activated carbon, and vacuum-dried to obtain the finished product of ergosterol.

Embodiment 3

[0039] (1) Get 140kg of sodium hydroxide liquid (containing NaOH35%), 20kg of sodium chloride, put it into a saponification pot, add dry yeast powder 100kg under stirring, saponification temperature 102 ℃, saponification reaction 12h;

[0040] (2) Get toluene 312kg, add in saponification liquid and carry out extraction, extraction temperature is 70 ℃;

[0041] (3) washing

[0042] The toluene feed liquid after the extraction is washed with water to make the toluene feed liquid clear and transparent;

[0043] (4) concentrated

[0044] Put the toluene feed liquid into the concentration pot to concentrate, then add ethanol to dissolve, and stand to crystallize to obtain the crude ergosterol;

[0045] (5) refined

[0046] The crude product of ergosterol was dissolved in a mixed solvent of toluene and ethanol (1:2), then filtered through activated carbon, and vacuum-dried to obtain the finished product of ergosterol.

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Abstract

The invention relates to a preparation method to produce ergosterol with yeast in fine chemical industry, which comprises: mixing the yeast, base and sodium chloride solution for saponification, extracting by toluene, cleaning with water, condensing, refining, and drying in vacuum. This method has convenient process with low cost and provides material guarantee for vitamin D2.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to the field of a preparation method for producing ergosterol with yeast. Background technique [0002] Ergosterol is the most important phytosterol, present in yeast and some plants, when it is irradiated by ultraviolet light, one of the four carbon rings in the molecule breaks and becomes vitamin D 2 , which is industrially mass-produced vitamin D 2 main raw material. due to vitamin D 2 It is one of the trace organic compounds necessary for humans and animals to maintain normal life activities and health. Vitamin D can be added in moderation in medicines, food and feed 2 To meet the regular intake of people or animals from the outside world. Vitamin D 2 At present, the annual consumption in the world is about 1,800 tons, of which about 70% is used for feed additives. The annual demand in my country is about 100 tons, and vitamin D in my country 2 The annual production...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 陈国苹
Owner SICHUAN NEIJIANG HUIXIN PHARMA
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