Phospholipid complex containing silybin di-partial succinate, preparation method and application thereof

A dimesuccinate and phospholipid complex technology, applied in the field of medicine, can solve the problems of poor water solubility and low bioavailability, increase fat solubility, improve bioavailability, expand the scope of application and the way of drug delivery Effect

Inactive Publication Date: 2010-12-29
天津康鸿医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main ingredient of Cilibenan Tablets is silybin meglumine, but it still has the disadvantage of low bioavailability
The main ingredient of Shuilinjia is silybin lecithin complex, although the bioavailability has been improved to a certain extent by improving the fat solubility, but its water solubility is still poor

Method used

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  • Phospholipid complex containing silybin di-partial succinate, preparation method and application thereof
  • Phospholipid complex containing silybin di-partial succinate, preparation method and application thereof
  • Phospholipid complex containing silybin di-partial succinate, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 silybin dimesuccinate phospholipid complex 1

[0033] Mix 500.0g of silibinin dimetasuccinate and 500.0g of soybean lecithin evenly, dissolve in 20000ml of absolute ethanol, heat at 50°C, the solution is clear after 5h, concentrate and dry under reduced pressure at 70°C to obtain silybin dimetasuccinate Succinate Phospholipid Complex.

Embodiment 2

[0034] The preparation of embodiment 2 silibinin dimetasuccinate phospholipid complex 2

[0035] Mix 500.0g of silibinin dimetasuccinate with 1000.0g of soybean lecithin, dissolve in 20000ml of absolute ethanol, heat at 50°C, the solution is clear after 5h, concentrate and dry under reduced pressure at 70°C to obtain silibinin dimetasuccinate ester phospholipid complex.

Embodiment 3

[0036] Embodiment 3 The preparation of silibinin dimetasuccinate phospholipid complex 3

[0037] Mix 500.0g of silibinin dimetasuccinate and 1500.0g of lecithin, dissolve in 20000ml of absolute ethanol, heat at 50°C, the solution is clear after 5h, concentrate and dry under reduced pressure at 70°C to obtain silybin dimetasuccinate ester phospholipid complex.

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Abstract

The invention discloses a medical complex containing silybin di-partial succinate, a preparation method and an application thereof. The silybin di-partial succinate and phospholipid are dissolved in an organic solvent based on a certain ratio, drying and concentration are carried out after heating and refluxing, and the product is obtained. The complex not only enhances the solubility of silybin but also enhances the lipid solubility and obviously improves the problem of low bioavailability. The complex has the effect of protecting a liver and can be used in the therapy of acute and chronic hepatitis, fatty liver and other liver dysfunctions.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a phospholipid complex containing the active ingredient silybin dimesuccinate. The specific feature of the complex is that it can obviously improve its fat solubility and improve its bioavailability while increasing its water solubility. , to play a better curative effect in protecting the liver. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of fatty liver in my country has approached the carrier rate of hepatitis B virus, and it is showing a clear upward trend. Among them, men aged 30 to 40 are the "main force" in the army of fatty liver patients, basically accounting for 1 / 4 of all fatty liver patients. It is estimated that the incidence of fatty liver is now about 30 times higher than that before the 1980s. It is reported that 15% of patients with fatty liver will develop ci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61K47/24A61P1/16
Inventor 吴疆李鹏旺邹美香孙歆慧张彩霞
Owner 天津康鸿医药科技发展有限公司
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