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Biochip and production method thereof

A biochip and chip carrier technology, applied in biochemical equipment and methods, microbiological measurement/inspection, instruments, etc., can solve the problems of poor repeatability of experimental results, unstable experimental results, unstable probe molecules, etc., and it is not easy to achieve Broken, stable in nature, not easy to lose effect

Inactive Publication Date: 2011-01-12
深圳博尔美生物科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0002] Traditional carriers used to prepare biochips mainly include glass slides, silicon wafers, metal sheets, nylon membranes, etc. Silicon wafers, metal sheets, and nylon membrane chips are expensive, and glass chips are often used as carriers for ordinary chips, but glass chips are fragile and fragile. The coated organic film is easy to fall off, the probe molecules are unstable, the repeatability of the experimental results is poor, and the experimental results are unstable

Method used

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  • Biochip and production method thereof
  • Biochip and production method thereof
  • Biochip and production method thereof

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Embodiment Construction

[0021] The structure and preparation method of the biochip will be described below mainly in conjunction with the accompanying drawings and specific examples.

[0022] By immobilizing the coating layer at the bottom of the well of the multi-well plate (such as 12, 24, 48, 96, 384 micro-well plate, etc.) used in ELISA, and then placing probe molecules on the coating layer, compared with the traditional glass Material biochip, due to the good adsorption between the plastic and the coating layer, the probe molecules are not easy to fall off, and because the plastic chip is not easy to break, the sample to be tested is not easy to lose, and the experimental results are more reliable and stable.

[0023] like figure 1 Shown is the top view of the biochip in the preferred embodiment. The multi-microwell plate used is consistent with the standard ELISA multi-microwell plate commonly used in the laboratory. Each hole is a chip, which is arranged into a chip strip of 12×8 array. Every...

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Abstract

The invention relates to a biochip and a production method thereof, the biochip adopts a microporous plate as a chip barrier, the bottom of each pore of the microporous plate is coated with a coating layer, and a probe which crossbreeds with a substance to be detected is fixed on the coating layer. As the coating layers are fixed at the bottoms of the plastic pores of the microporous plate used by ELISA and are dotted and provided with probe molecules, compared with the traditional biochip made of glass materials, as the adsorptivity between plastics and the coating layers is good, the probe molecules are not easy to fall off, simultaneously, the chip is not easily broken, the sample to be detected is not easily lost, and the experimental result is more reliable and stable.

Description

【Technical field】 [0001] The invention relates to a biological chip and a preparation method thereof. 【Background technique】 [0002] Traditional carriers used to prepare biochips mainly include glass slides, silicon wafers, metal sheets, nylon membranes, etc. Silicon wafers, metal sheets, and nylon membrane chips are expensive, and glass chips are often used as carriers for ordinary chips, but glass chips are fragile and fragile. The coated organic film is easy to fall off, the probe molecules are unstable, the repeatability of the experimental results is poor, and the experimental results are unstable. 【Content of invention】 [0003] Based on this, it is necessary to provide a stable biochip with immobilized probe molecules. [0004] At the same time, it is also necessary to provide a biochip preparation method with fixed probe molecules and stability. [0005] A biological chip, using a multi-microhole plate as a chip carrier, a coating layer is fixed on the bottom of...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/543
Inventor 庄卫东顾大勇杨泽李永进张巍
Owner 深圳博尔美生物科技有限公司
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