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Antitubercular pharmaceutical composition containing balloonflower root extract

A platycodon grandiflorum extract and anti-tuberculosis technology, which is applied to an anti-tuberculosis drug composition, a combination of a traditional Chinese medicine platycodon grandiflorum extract and an anti-tuberculosis drug in the application field of the medical field, can solve the problems of pulmonary tuberculosis that are not documented in literature and the like, and achieves improved effective killing. The ability of Mycobacterium tuberculosis, less liver damage, and the effect of reducing drug resistance of Mycobacterium tuberculosis

Inactive Publication Date: 2011-04-13
张瑶纾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been documented or reported in combination with anti-tuberculosis drugs for the treatment of pulmonary tuberculosis.

Method used

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  • Antitubercular pharmaceutical composition containing balloonflower root extract
  • Antitubercular pharmaceutical composition containing balloonflower root extract
  • Antitubercular pharmaceutical composition containing balloonflower root extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] 200g of Platycodon grandiflora, 80% ethanol as solvent, material-to-liquid ratio 1:10, 1:8, 1:6, reflux extraction in 90°C water bath for 3 times, 1.0h each time, suction filtration while hot after each reflux, and combine the filtrates , concentrated to obtain extract 82.2g.

Embodiment 2

[0198] Accurately weigh 200g of Platycodon grandiflorum, add 50% ethanol with a solid-liquid ratio of 1:8, ultrasonically extract for 30 minutes, extract 3 times, combine the filtrates, concentrate, and freeze-dry to obtain 61.8g of extract.

Embodiment 3

[0200] Accurately weigh 20 g of Platycodon grandiflorum, add 95% ethanol with a ratio of solid to liquid of 1:10, ultrasonically extract for 30 min, extract 3 times, combine the filtrates, concentrate, and freeze-dry to obtain 66.9 g of extract.

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PUM

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Abstract

The invention relates to an antitubercular pharmaceutical composition containing balloonflower root extract, which is prepared from the components of 0.1-100 parts of balloonflower root extract by weight and 1 part of antitubercular drug by weight through the steps as follows: extracting the balloonflower root extract for three times by water or extracting the balloonflower root extract for three times by 40-95% ethanol at the temperature of 90 DEG C, and concentrating, wherein the weight measurement ratio of the balloonflower root extract to the water is 1:(6-10), and the weight measurement ratio of the balloonflower root extract to the ethanol is 1:(5-15). The pharmaceutical composition in the invention has the functions of enriching the antitubercular drugs in lung tissues and improving the potency of the antitubercular drugs for curing phthisis as compared with single antitubercular drugs, and simultaneously has the positive effects such as reducing the liver injury caused by the antitubercular drugs and the like. By utilizing he pharmaceutical composition, the phthisis therapeutic window of the antitubercular drugs can be amplified, and the capability of effectively killing tubercle bacillus is enhanced, thereby increasing the potency, shortening the treatment cycle and lowering the possibility of tolerance of tubercle bacillus.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to the application of the combination of Chinese medicine bellflower extract and anti-tuberculosis drug in the field of medicine. More specifically, it is an anti-tuberculosis drug composition containing Platycodon grandiflorum extract. Background technique [0002] Pulmonary tuberculosis is a human infectious disease. According to the statistics of relevant departments, there are several million people in my country with active pulmonary tuberculosis patients in recent years. Once tuberculosis is infected, some people will not heal for life, and the treatment process of general diseases will take at least half a year. At present, tuberculosis is still a common and frequently-occurring disease in my country, and it is one of the top ten causes of death among the sick population in my country. [0003] Anti-tuberculosis chemical drug treatment plays ...

Claims

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Application Information

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IPC IPC(8): A61K36/34A61P31/06A61K31/4409A61K31/496A61K31/4965A61K31/606
Inventor 张瑶纾吴志丽周晶
Owner 张瑶纾
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