5-benzyl-4-alkyl-2-aminothiazole as well as preparation and application of 5-benzyl-4-alkyl-2-aminothiazole

Abstract

The invention discloses 5-benzyl-4-alkyl-2-aminothiazole as shown in a chemical structure formula I and pharmaceutically acceptable salts of the 5-benzyl-4-alkyl-2-aminothiazole as shown in the specification. A preparation method of the 5-benzyl-4-alkyl-2-aminothiazole is as follows: heating 2-haslogen-1-aryl alkyl ketone, alkyl thiourea and ethanol, stirring, and reacting for a certain time; filtering, drying to obtain5-benzyl-4-alkyl-2-aminothiazole salts; and filtering the obtained filter cake and neutralizing with ammonia water, and then obtaining 5-benzyl-4-alkyl-2-aminothiazole. The invention also discloses application of the 5-benzyl-4-alkyl-2-aminothiazole or salts thereof in preparing antitumor medicaments.

Description

technical field [0000] The present invention relates to a new compound and its application in the preparation of antitumor drugs, in particular to the synthesis of 5-benzyl-4-alkyl-2-arylaminothiazole and its application in the preparation of antitumor drugs. Background technique [0000] The development of heterocyclic compounds shows a trend of diversification, among which thiazole compounds are a new bright spot in recent years. Heterocyclic compounds containing thiazole rings often have broad-spectrum biological activities. Many thiazole compounds can be used as local anesthetics, with anticonvulsant, antiviral, antibacterial and insecticidal effects. Because of its simple structure, 2-aminothiazole compounds are more used as synthetic intermediates such as medicines and pesticides, through which thiazole groups are introduced into various compound structures, and a series of compounds with broad spectrum can be produced through structural modification. Bioactive compou...

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There is no research report on the synthesis and antitumor activity of 5-benzyl-4-alkyl-2-arylaminothiazole

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