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Application of ginkgo leaf total lactones in preparation of medicament for preventing or treating deafness and tinnitus

A technology for ginkgolides and deafness and tinnitus, which is applied in the application field of ginkgo biloba total lactones in the preparation of drugs for the prevention or treatment of deafness and tinnitus, and can solve the problem that ginkgo leaves have no effect on tinnitus

Active Publication Date: 2011-06-01
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are also reports that Ginkgo leaves are not effective in treating tinnitus (Health Companion Magazine)

Method used

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  • Application of ginkgo leaf total lactones in preparation of medicament for preventing or treating deafness and tinnitus
  • Application of ginkgo leaf total lactones in preparation of medicament for preventing or treating deafness and tinnitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 (the used raw material Ginkgo biloba obtains by commercially available)

[0015] Step 1 extract and concentrate

[0016] Take 100kg of ginkgo leaves, soak in 400kg of 90% alcohol overnight; reflux at 70°C for 3 hours, filter, add 400kg of pure water to the residue, stir and reflux at 70°C for 2 hours, combine the two extracts, concentrate under reduced pressure until no alcohol smell, The vacuum degree is -0.085Mpa, and the temperature is 50-55°C;

[0017] Step 2 First upload

[0018] Add 80kg of hot water at 35-40°C to the concentrated solution in step 1 to dilute, then add 300kg of cold water to dilute, and let stand for 12 hours; take the supernatant and dilute to a density of 1-1.1g / ml, put it on a macroporous resin column (D101), First rinse with 100kg of pure water, then rinse with 15% ethanol with a pH value of 7.0, and then elute with 60% ethanol. When the color band moves down to the outlet, the color of the effluent becomes darker, and the eluat...

Embodiment 2

[0033] Example 2 Ginkgo biloba extract and ginkgo biloba total lactones to the protective effect of rat hearing

[0034] Drugs: Ginkgo biloba leaves (commercially available, each tablet contains 80mg of Ginkgo biloba extract)

[0035] Ginkgo biloba total lactones (self-made embodiment 1, content 65%)

[0036] Animals: SD rats (provided by the Experimental Animal Center of Second Military Medical University);

[0037] Ginkgo biloba group (each tablet contains 80mg of ginkgo leaf extract);

[0038] Ginkgo biloba total lactone group (content 65%, high dose: 9.2mg / kg / day; medium dose 4.6mg / kg / day; small dose 2.3mg / kg / day)

[0039] Get 72 SD rats, body weight 250-280g, be divided into six groups at random: normal control group, noise group, Ginkgo Leaf (each sheet contains Ginkgo Leaf extract 80mg) group, Ginkgo Leaf Total Lactone (self-made embodiment 1) The high-dose group, the medium-dose group of total ginkgo biloides, and the low-dose group of total ginkgo biloides, the nor...

Embodiment 3

[0045] Self-made Example 1 Ginkgo biloba total lactones 25g, crushed into 150 mesh fine powder, added 150g of lactose, mixed uniformly, boiled and granulated, added micronized silica gel 3g, magnesium stearate 2g in the granules, mixed uniformly, packed into 2# capsules, Made into 1000 capsules for the treatment of deafness and tinnitus. Usage: take orally, 1 capsule each time, 2 times a day.

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PUM

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Abstract

The invention discloses application of ginkgo leaf total lactones in preparation of a medicament for preventing or treating deafness and tinnitus. The ginkgo leaf total lactones are extracted from ginkgo leaves, the lactone component content is 50 to 99 percent by HPLC (High Performance Liquid Chromatography) detection, and the ginkgo leaf total lactones mainly comprise four chemical components, namely ginkgo lactone A, ginkgo lactone B, ginkgo lactone C and ginkgo seed lactone. The inventor performs experiments of the ginkgo leaf total lactones on a rat audition effect, and the results show that the ginkgo leaf total lactones have certain protection effect on the rat audition, the effect of the ginkgo leaf total lactones is obviously superior to that of ginkgo leaf extract and a quantitative effect relationship is formed. Therefore, the ginkgo leaf total lactones can be used for preparing the medicament for preventing or treating the deafness and the tinnitus. The medicament is a medicinal composition prepared from the ginkgo leaf total lactones and medicinal auxiliary materials according to a conventional method. The medicament can be prepared into oral preparations such as tablets, capsules and the like, can also be prepared into injection preparations such as injection, freeze-dried powder and the like, and can further be prepared into patches and the like.

Description

technical field [0001] The invention relates to traditional Chinese medicines, in particular to the application of ginkgo biloba total lactones in the preparation of medicines for preventing or treating deafness and tinnitus. Background technique [0002] Deafness can be roughly divided into clinical deafness: acoustic deafness caused by lesions of the outer ear and middle ear; sensorineural deafness caused by lesions of the inner ear and auditory nerve; and mixed deafness caused by common lesions of the outer and middle ear and the auditory nerve of the middle ear . There are many reasons for deafness, such as heredity, birth trauma, infection, improper application of drugs, immune diseases, degeneration of physiological functions, poisoning of certain chemical substances, etc. can all lead to deafness. [0003] Sensorineural deafness (neurosensory deafness) refers to cochlear spiral organ lesions cannot convert sound waves into nerve excitations or nerves and their centra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P27/16A61K127/00
Inventor 胡林森
Owner SHANGHAI SINE PROMOD PHARMA
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