Application of compound danshen dripping pills in preparation of medicines for treating microcirculation disturbance and myocardial fibrosis

A technology for myocardial fibrosis and microcirculation disorder, applied in the field of medicine, can solve problems such as unclear microcirculation disorder, and achieve the effect of improving cardiac microcirculation disorder and myocardial injury.

Inactive Publication Date: 2011-06-22
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not clear whether administration of Compound Danshen Dropping Pills can improve microcirculation disturbance and myocardial injury caused by ischemia-reperfusion

Method used

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  • Application of compound danshen dripping pills in preparation of medicines for treating microcirculation disturbance and myocardial fibrosis
  • Application of compound danshen dripping pills in preparation of medicines for treating microcirculation disturbance and myocardial fibrosis
  • Application of compound danshen dripping pills in preparation of medicines for treating microcirculation disturbance and myocardial fibrosis

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Embodiment 1

[0022] 1. Materials and methods

[0023] 1.1 Animals

[0024] Male SD rats, weighing 240-260 g, were purchased from the Animal Center of Peking University Medical Department, certificate number: SCXK (Beijing) 2006-0001. The management of experimental animals is carried out in accordance with the guidelines for the management of experimental animals issued by the Ministry of Health.

[0025] 1.2 Drugs and Reagents

[0026] Compound Danshen Dropping Pills (batch number: 200605027) were provided by Tianjin Tasly Pharmaceutical Co., Ltd. (Tianjin, China), and were produced in strict accordance with the requirements of the Good Manufacturing Practice for Drugs and the Standards for Drug Safety Testing. The content of its main components was determined by HPLC fingerprints Determination. Before the experiment, the appropriate concentration [(25mg / 100mg / 200mg) / ml] was prepared with normal saline and administered by gavage.

[0027] FITC-labeled albumin was purchased from Sigma C...

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Abstract

The invention discloses application of compound danshen dripping pills in preparation of medicines for treating microcirculation disturbance and myocardial fibrosis. The compound danshen dripping pills are administrated after heart ischemia reperfusion so as to effectively treat myocardial fibrosis injury caused by the ischemia reperfusion and improve heart microcirculation disturbance caused by improving the ischemia reperfusion.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of compound Danshen dripping pills in the preparation of medicines for treating microcirculation disorders and myocardial fibrosis. Background technique [0002] Although great progress has been made in the research and clinical treatment of cardiovascular disease, the morbidity and mortality of ischemic heart disease are still high. It is reported that about 7 million people worldwide suffer from sudden cardiac death every year. Reperfusion itself can lead to cardiomyocyte apoptosis during thrombolysis, cardiac resuscitation, and coronary artery bypass grafting, a pathological process known as myocardial ischemia-reperfusion (I / R). [0003] Recent studies have found that ischemia-reperfusion-induced microcirculation disturbances may cause myocardial damage and further lead to cardiac dysfunction. Reactive oxygen species and inflammatory mediators produced after leukocyt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P9/10A61P9/00A61K31/045
Inventor 韩晶岩卫晓红刘育英胡白和常昕赵娜
Owner TIANJIN TASLY PHARMA CO LTD
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