Serum protein mass spectrum model for screening pancreatic cancer and construction method thereof

A construction method and protein technology, which can be used in measurement devices, material analysis by electromagnetic means, instruments, etc., can solve the problems that the specificity and sensitivity cannot meet the requirements of early diagnosis, the difficulty and increase of pancreatic cancer, and the construction method is reasonable and feasible. , high sensitivity and specificity, and highly operable effects

Inactive Publication Date: 2011-07-20
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most desirable model for early diagnosis of pancreatic cancer is for high-risk groups (elderly men, those with long-term smoking and alcohol history, or those with chronic pancreatitis, diabetes, high-fat diet, occupations that are in contact with carcinogens, and those with family history of pancreatic cancer ) Regular screening and screening, but it is difficult to use this model for pancreatic cancer
Although some commonly used tumor markers such as CA19-9, CA50, CA242, etc. play an important role in the diagnosis of pancreatic cancer, evaluation of its prognosis and monitoring of recurrence, their specificity and sensitivity cannot meet the needs of early diagnosis , because these indicators are not elevated in localized pancreatic cancer without metastasis, but they are also elevated in non-pancreatic cancer patients, so it is necessary to find new specific indicators to further improve the early diagnosis of pancreatic cancer

Method used

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Embodiment Construction

[0023] The serum protein spectrum model for screening pancreatic cancer provided by the invention can perform early screening for suspected pancreatic cancer patients and provide a basis for further discovery of possible tumor markers.

[0024] The serum protein spectrum model for screening pancreatic cancer in the present invention is located at 4976±380Da, 6857±737Da, 4407±726Da, 5488±963Da, 7068±142Da, 3250±591Da, 4753 Human serum protein composition at ±360 Da, 6885±572 Da, 5644±382 Da, 2892±299 Da, 3281±348 Da, 4292±289 Da, 2678±208 Da and 5364±126 Da.

[0025] The construction method of mass spectrum model of the present invention comprises the following steps:

[0026] 1. Collection, processing and binding of serum to protein chips.

[0027] Serum collection, processing, and protein chip (CM10) combination: including collecting serum from various patients who meet the inclusion criteria, such as pancreatic cancer, chronic pancreatitis, pancreatic benign tumor patients ...

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Abstract

The invention discloses a serum protein mass spectrum model for screening pancreatic cancer and a construction method thereof. The serum protein mass spectrum model mainly comprises human serum proteins, the cytoplasm-nuclear ratios (M / Z) of which are positioned at 4,976+ / -380Da, 6,857+ / -737Da, 4,407+ / -726Da, 5,488+ / -963Da, 7,068+ / -142Da, 3,250+ / -591Da, 4,753+ / -360Da, 6,885+ / -572Da, 5,644+ / -382Da, 2,892+ / -299Da, 3,281+ / -348Da, 4,292+ / -289Da, 2,678+ / -208Da and 5,364+ / -126Da in human serum protein mass spectrums. The construction method is reasonable, feasible and simple and convenient in operation, and can be used for batch processing.

Description

technical field [0001] The invention relates to the technical field of detection, in particular to a serum protein spectrum model for screening pancreatic cancer and a construction method thereof. Background technique [0002] Pancreatic cancer is a relatively common malignant tumor of the digestive system. Due to the deep location of the pancreas, it is hidden and highly invasive, so the surgical resection rate is low and the prognosis is poor. The 5-year survival rate is less than 6%, and it is called "the king of cancer". . Improving the early diagnosis rate is of great significance to improving the long-term survival rate of pancreatic cancer, so finding an ideal method for early differential diagnosis such as specific serum or pancreatic juice protein markers is the key to solving this problem. The most desirable model for early diagnosis of pancreatic cancer is for high-risk groups (elderly men, those with long-term smoking and alcohol history, or those with chronic p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64
Inventor 蔡建庭陈妙研
Owner ZHEJIANG UNIV
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