Tibetan capillaris extract and preparation method, pharmaceutical composition and use thereof

A technology of extracts and compositions, applied in the field of extracts and preparations of capillary capillaries, can solve the problems of less prominent medicinal effects and complex components of products, and achieve the effect of saving resources and reducing costs

Active Publication Date: 2011-08-03
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] As mentioned above, the current inventions and methods of Chinese patent reports on Tibetan capillary drugs (including Swertia genus medicinal plants) produce products of Tibetan capillary plants with relatively complicated ingredients, and the characteristics of medicinal effects are not very prominent.

Method used

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  • Tibetan capillaris extract and preparation method, pharmaceutical composition and use thereof
  • Tibetan capillaris extract and preparation method, pharmaceutical composition and use thereof
  • Tibetan capillaris extract and preparation method, pharmaceutical composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The preparation technology of embodiment 1 Tibetan fungi extract

[0055] Take 20 kg of western Sichuan Swertia medicinal material, powder it into small pieces, put it in a 300-liter extraction tank, add 10 times the amount of 90% ethanol, extract three times, each time for 2 hours, collect the extract, and recover the ethanol under reduced pressure until it has no alcohol smell, and obtain Concentrate;

[0056] Add 2 times the amount of water to the above concentrated solution, stir while adding water, let it stand for 24 hours, centrifuge, collect the filtrate and filter residue separately, and set aside;

[0057] Weigh 20kg of HPD-100 resin, place it in a resin column, pretreat with 95% ethanol and water respectively, then add the filtrate obtained above, flow rate 1BV / h, and discard the effluent; then elute with 3BV of water, Flow rate 1BV / h, discard the water eluent; then use 8BV of 30% ethanol for elution, flow rate 1BV / h, collect 30% ethanol eluate, concentrat...

Embodiment 2

[0061] The preparation technology of embodiment 2 Tibetan fungi extract

[0062] Take 20kg of Swertia clam medicinal material, powder it into small pieces, put it in a 300-liter extraction tank, add 12 times the amount of 80% ethanol, extract twice, 3 hours each time, collect the extract, and recover the ethanol under reduced pressure until it has no alcohol smell , to obtain a concentrated solution;

[0063] Add 5 times the amount of water to the concentrated solution, stir while adding water, let it stand for 12 hours, centrifugally filter, collect the filtrate and filter residue separately, and set aside;

[0064] Weigh 20kg of D-101 resin, place it in a resin column, pretreat with 95% ethanol and water respectively, then add the filtrate obtained above, flow rate 2BV / h, discard the effluent; then elute with 5BV of water, Flow rate 1BV / h, discard the water eluate; then use 6BV of 20% ethanol for elution, flow rate 1BV / h, collect 20% ethanol eluate, concentrate under redu...

Embodiment 3

[0068] The preparation technology of embodiment 3 Tibetan fungi extract

[0069] Take 20kg of Western Sichuan Swertia herb, powder it into small pieces, put it in a 300-liter extraction tank, add 15 times the amount of 65% ethanol, extract twice, 1.5 hours each time, collect the extract, and recover the ethanol under reduced pressure until it has no alcohol smell. obtain a concentrate;

[0070] Add 3 times the amount of water to the concentrated solution, stir while adding water, let stand for 36 hours, centrifuge, collect the filtrate and filter residue separately, and set aside. Weigh 20kg of HPD-300 resin, place it in a resin column, pretreat with 95% ethanol and water respectively, then add the filtrate obtained above, flow rate 3BV / h, and discard the effluent; then elute with 4BV of water, Flow rate 1.5BV / h, discard the water eluate; then elute with 8BV of 10% ethanol, flow rate 1.5BV / h, collect 10% ethanol eluate, concentrate under reduced pressure, and carry out vacu...

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Abstract

The invention provides a Tibetan capillaris extract, which comprises components of secoiridoid, xanthone, triterpene and the like, wherein the total content of the three components is 20%-80% (by weight). The invention also provides a preparation method of the Tibetan capillaris extract, and a pharmaceutical composition containing the Tibetan capillaris extract. The Tibetan capillaris extract hasthe obvious function of benefiting the cholecyst, and has obvious functions of protecting and improving acute liver injury caused by chemicals and hypohepatia of obstructive jaundice.

Description

technical field [0001] The present invention belongs to the technical field of medicine, and specifically relates to a Tibetan capillary extract and a preparation method thereof, a pharmaceutical composition containing the Tibetan capillary extract and its application. Background technique [0002] Tibetan Yinchen is a traditional Tibetan medicine in my country. It is recorded in the classic works of Tibetan medicine "Jingzhu Materia Medica" and "Tibetan Medicine Jingjing Materia Medica". It is called "Tida" in Tibetan medicine. The original plant source mainly includes Gentianaceae plants Indian Swertia, Western Sichuan Swertia, Swertia spp., Pulan Swertia, flower anchors, flat buds, cruciferous plants such as long fructose mustard, saxifrage plants, saxifrage, etc. S. mussotii and S. franchetiana, as the original plants of Tibetan fungus, were recorded in the Tibetan medicine standard or local standard of the Ministry of Health. The main function of Tibetan Yinchen is to cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/08A61K9/19A61K9/16A61K9/20A61K9/48A61P1/16
Inventor 张铁军田成旺王丽莉朱雪瑜龚苏晓韩冬刘莹
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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