Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of creatine phosphate sodium in preparing antishock medicament

A sodium creatine phosphate, anti-shock technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc., to achieve the effects of good safety, good liver and kidney protection function, and significant drug efficacy

Active Publication Date: 2011-10-12
JILIN YINGLIAN BIOPHARML
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no literature at home and abroad to report that creatine phosphate sodium has anti-shock medicinal activity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of creatine phosphate sodium in preparing antishock medicament
  • Application of creatine phosphate sodium in preparing antishock medicament
  • Application of creatine phosphate sodium in preparing antishock medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The impact of embodiment 1 creatine phosphate sodium on rat shock model

[0018] 1. Test material

[0019] (1) Test article: sodium creatine phosphate

[0020] (2) Test animals: SD male rats

[0021] (3) Instrument: BL-420E biological function test system

[0022] 2. Model establishment

[0023] Take 40 healthy male rats, weighing 300-330 g, fast for 12 hours before the test, and drink water freely during the test. They were randomly divided into 4 groups: sham operation group, model group (model control group), low-dose model administration group (low-dose creatine phosphate sodium group), high-dose model administration group (high-dose creatine phosphate sodium group). 10 in each group.

[0024] During the test, after intraperitoneal injection of pentobarbital sodium 35 mg / kg anesthetized, the animals were fixed on the operating table in supine position. The operation site was sterilized with 75% ethanol after hair removal, and the right carotid artery and left ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of creatine phosphate sodium in preparing an antishock medicament, in particular the application of the creatine phosphate sodium in preparing a medicament for treating shock caused by mine accidents, electric shock, drowning and traumatic hemorrhage. Found by study, the creatine phosphate sodium can effectively improve the symptoms of hemorrhagic shock, inhibits generation of lactic acid due to anaerobic respiration under an anaerobic condition, has good liver and kidney protecting functions, and obviously prolongs the survival time of an animal with shock.

Description

technical field [0001] The invention relates to the application of creatine phosphate sodium in the preparation of anti-shock medicine, in particular to the application of creatine phosphate sodium in the preparation of medicine for treating shock caused by various reasons. Background technique [0002] Shock refers to a state in which the perfusion of surrounding tissues is insufficient due to insufficient cardiac output or abnormal distribution of peripheral blood flow, which cannot sustain life. Usually, there are hypotension and oliguria. [0003] Shock can be caused by hypovolemia, vasodilation, cardiogenic, or a combination of these factors. The basic damage of shock is the decreased perfusion of various organs and tissues caused by hypotension, so due to O 2 Insufficient transport or intake of lactic acid, tissue cells cannot maintain the needs of aerobic metabolism, and turn to anaerobic metabolism, resulting in increased production and accumulation of lactic acid. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/664A61P9/00
Inventor 芦志刚
Owner JILIN YINGLIAN BIOPHARML
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com