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Chinese medicinal oral liquid capable of eliminating medicine resistance plasmid of escherichia coli of chicken

A technology of ciprofloxacin hydrochloride and neomycin sulfate, which is applied in the directions of drug delivery, digestive system, antibacterial drugs, etc., can solve problems such as toxic side effects, inconvenient clinical application, etc., and achieve the effect of reducing symptoms

Inactive Publication Date: 2013-06-05
HEBEI UNIV OF ENG
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Problems solved by technology

However, because these factors have strong toxic and side effects on the body, it is inconvenient for clinical application.

Method used

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Embodiment Construction

[0022] List 10 specific embodiments of the present invention below, all ingredients are purchased directly from the market, and its production process is: ① sorting, that is, to remove impurities in each component, ② superfine pulverization, that is, respectively The above-mentioned components are weighed and mixed, crushed into 200-mesh fine powder, ③soaking, that is, the crushed medicinal powder is soaked in water 5 times the weight of the medicinal powder at room temperature for 3 hours, ④ultrasonic extraction, that is, from the soaked medicinal liquid mixture Under the condition of 60°C, use ultrasonic extraction for one hour, that is, separate the drug powder residue from the drug solution from the soaked drug solution mixture, and keep the drug solution for later use. The residue is then soaked in clear water 5 times the weight of the original drug powder for 3 hours at room temperature, ⑥ ultrasonically extracted again, that is, the drug powder residue and the drug solut...

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Abstract

The invention discloses Chinese medicinal oral liquid combining with ciprofloxacin or neomycin sulfate capable of eliminating medicine resistance plasmid in chicken colibacillosis, which is prepared from the following raw material medicines: 45 to 55 grams of astragalus, 45 to 55 grams of folium artemisiae argyi, 45 to 55 grams of root of red-rooted salvia, 45 to 55 grams of dandelion, 25 to 35 grams of rhubarb, 45 to 55 grams of sanguisorba officinalis, 45 to 55 grams of Chinese violet, 45 to 55 grams of artemisia apiacea, 25 to 35 grams of red paeony root, and 15 to 25 grams of liquoric root. The preparation process comprises: 1, sorting; 2, grinding; 3, soaking; 4, ultrasonic extraction; 5, concentration; 6, filtering; 7, adding anticorrosion agent; and 8, packing separately. The Chinese medicinal oral liquid has good treatment effect on infectious bursal disease, basically avoids residual and has high biological safety.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating bacterial enteritis, in particular to a traditional Chinese medicine oral liquid used in combination with ciprofloxacin hydrochloride or neomycin sulfate to eliminate drug-resistant plasmids of chicken Escherichia coli. Background technique [0002] At present, bacterial enteritis in chickens is mainly treated with antibiotics. The wide application of antibiotics has brought some diseases caused by bacteria under control, but the morbidity and mortality are still high. The reason is related to the emergence of bacterial drug resistance (especially multi-drug resistance). Drug resistance is mainly mediated by chromosomes or drug-resistant plasmids (R-plasmids). R-plasmids can be transmitted between different strains through conjugation, transformation, and transduction, making susceptible bacteria resistant to drugs, resulting in the prevalence of R-plasmids. The transfer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K9/00A61P31/04A61P1/00
Inventor 张登荣王世英
Owner HEBEI UNIV OF ENG
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