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Application of sanguinarine in the preparation of sensitizing drugs for improving the antitumor efficacy of cisplatin

An anti-tumor, sanguinarine technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., to achieve the effect of improving sensitivity

Inactive Publication Date: 2011-12-21
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, there is no report on the sensitization effect of the sanguinarine to improve the therapeutic effect of cisplatin on tumors

Method used

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  • Application of sanguinarine in the preparation of sensitizing drugs for improving the antitumor efficacy of cisplatin
  • Application of sanguinarine in the preparation of sensitizing drugs for improving the antitumor efficacy of cisplatin
  • Application of sanguinarine in the preparation of sensitizing drugs for improving the antitumor efficacy of cisplatin

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with accompanying drawing and embodiment:

[0019] (1) Materials: Human lung cancer H446 cells were purchased from ATCC, USA. Sanguinarine (≥98.0%, model: 84480), trypsin, living cell metabolite reducing agent thiazolyl blue (MTT), dimethyl sulfoxide (DMS O) were purchased from Sigma Company in the United States, D-MEM medium and serum Purchased from Gibcol Corporation. Inverted CKX41 microscope and C-7070 digital camera were purchased from OLYMPUS Company.

[0020] Sanguinarine was dissolved in DMSO to prepare a 2 mmol / L stock solution, which was stored at -20°C for future use. Prepare to the required concentration with complete medium before use.

[0021] (2) Cell culture: Lung cancer cells in the logarithmic growth phase were inoculated and cultured at 37°C, containing 5% CO 2 24 hours under saturated humidity conditions. Directly use culture medium to dilute sanguinarine to the concentration r...

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Abstract

The invention belongs to the field of sensitizing drugs for tumor chemotherapy, and relates to a new application of sanguinarine, that is, the application in the preparation of sensitizing drugs for improving the curative effect of cisplatin chemotherapy. The sanguinarine described in the invention can be used to prepare a sensitizing drug for improving the curative effect of cisplatin chemotherapy, and can improve the curative effect of cisplatin chemotherapy for tumor cells at a low concentration without toxic or side effects. After treatment with sanguinarine at a concentration without toxic side effects, when combined with cisplatin chemotherapy, compared with cisplatin chemotherapy alone, the cell death rate increased by 100%, almost doubled.

Description

technical field [0001] The invention belongs to the field of tumor chemotherapeutic sensitization drugs, and relates to the new application of sanguinarine, that is, the application in the preparation of sensitization drugs for improving the curative effect of anti-tumor drug cisplatin. Background technique [0002] Chemotherapy is a treatment method that uses chemical drugs to kill tumor cells, inhibit the growth and reproduction of tumor cells, and promote the differentiation of tumor cells. Therapeutic effect, but chemotherapy to treat tumors kills both normal cells and immune (resistance) cells while killing tumor cells. After chemotherapy, decreased immune function, decreased white blood cells and platelets, and even decreased red blood cells and hemoglobin and other myelosuppressive manifestations often occur, as well as gastrointestinal symptoms such as decreased appetite, reduced food intake, nausea, vomiting, abdominal distension, abdominal pain, diarrhea or constip...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P35/00A61K33/24
Inventor 徐加英樊赛军
Owner SUZHOU UNIV
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