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Purpose of icariin in preparation of medicines used for treating bronchial asthma

A technique for bronchial asthma and icariin, applied in the field of biomedicine

Inactive Publication Date: 2012-02-01
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no relevant research reports on the application of icariin in the prevention and treatment of asthma at home and abroad.

Method used

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  • Purpose of icariin in preparation of medicines used for treating bronchial asthma
  • Purpose of icariin in preparation of medicines used for treating bronchial asthma
  • Purpose of icariin in preparation of medicines used for treating bronchial asthma

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0019] (1) Experimental animals and grouping: Healthy and clean male SD rats, weighing 350±10 g, were purchased from Sichuan Bill Experimental Animal Company. The animals were kept in the Experimental Animal Center of Fudan University, and the feeding conditions were clean, with fixed light time and free intake of water and food. Animals were divided into 6 groups, including blank control group, model group, and icariin (low, medium, high dose) intervention group. The low dose is 5mg / kg, the medium dose is 10mg / kg, and the high dose is 20mg / kg. The administration method is intraperitoneal injection, once a day, for a total of 28 days.

[0020] (2) Main reagents and instruments: ovalbumin (Shanghai Livzon Dongfeng Biotechnology Co., Ltd.); aluminum hydroxide gel (Sigma.Co.); sodium pentobarbital (Shanghai Chemical Reagent Company, imported repackaging); IL -4, 13 kits (Biosource imported packaging); corticosterone kit (R & D company); ACTH radioimmunoassay kit (Institute of N...

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PUM

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Abstract

The invention belongs to the field of biomedicine, and relates to a novel medicinal purpose of a traditional Chinese medicine effective component icariin. The invention specifically relates to a purpose of icariin in the preparation of medicines used for treating bronchial asthma. Test results show that, icariin assists in ameliorating asthma rat lung tissue inflammations, inhibiting inflammatory in asthma rat blood serum, inhibiting inflammatory in asthma rat alveolar lavage fluid, regulating expression unbalance of asthma rat lung tissue Th1 / Th2 relevant cytokine, and regulating expression unbalance of asthma rat lung tissue Th1 / Th2 relevant transcription factor (T-bet / GATA-3). The traditional Chinese medicine effective component icariin provided by the invention can be adopted as an active component, and can be prepared with pharmaceutically acceptable carriers into medicine compositions used for bronchial asthma.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new medicinal application of icariin, an active ingredient of traditional Chinese medicine, in particular to the application of icariin in the preparation of medicines for preventing and treating bronchial asthma. Background technique [0002] Asthma is a chronic airway inflammatory disease. According to reports, its morbidity and mortality are increasing year by year, seriously threatening people's physical and mental health. Pathological studies on bronchial asthma have shown that a variety of inflammatory cells, cytokines and inflammatory mediators constitute a complex inflammatory network and participate in the occurrence and development of asthma. Previous studies have shown that the water decoction of Chinese herbal medicine Epimedium has a certain intervention effect on asthma, but the preventive and therapeutic effects have not yet appeared. [0003] Icariin is the main effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/06
Inventor 董竞成徐长青吴金峰刘宝君曹玉雪
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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