210 results about "Bronchitic asthma" patented technology

An objective of the present invention is to provide a method of testing for bronchial asthma or chronic obstructive pulmonary disease, a method of screening for candidate compounds for treating bronchial asthma or chronic obstructive pulmonary disease, and a pharmaceutical agent for treating bronchial asthma or chronic obstructive pulmonary disease. The present invention identified genes whose expression levels varied between respiratory epithelial cells that had been stimulated by IL-13 to induce the goblet cell differentiation, and unstimulated respiratory epithelial cells. The respiratory epithelial cells were cultured according to the air interface method. The genes were revealed to be useful as markers for testing for bronchial asthma or chronic obstructive pulmonary disease and screening for therapeutic agents for such diseases. Specifically, the present invention provides methods of testing for bronchial asthma or chronic obstructive pulmonary disease and methods of screening for compounds to treat the diseases based on the comparison of the expression levels of marker genes identified as described above.

An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I).

The compound represented by the formula (I) inhibits the increase of the intracellular calcium concentration, and therefore it is deemed to be useful as an agent for the prophylaxis and/or treatment of platelet aggregation, ischemic diseases in hearts and brains, immune deficiency diseases, allorgosis, bronchial asthma, hypertension, cerebrovascular spasm, various renal diseases, pancreatitis, Alzheimer's disease, etc.

The invention belongs to the technical field of medicine, and particularly relates to an amorphous ambroxol hydrochloride compound and a preparation method thereof. The amorphous ambroxol hydrochloride compound has high purity and stability, does not have obvious moisture absorption and weight increase even under the condition of high humidity, ensures that relative substances do not grow, and has higher dissolution rate than crystalline ambroxol hydrochloride. The invention also relates to an application of the amorphous ambroxol hydrochloride compound in preparation of medicine for the treatment of acute and chronic pulmonary diseases with the symptom of ropy sputum and difficult expectoration, phlegm eliminating treatment of acute exacerbation of chronic bronchitis, asthmatic bronchitis and bronchial asthma, prophylactic treatment of lung complication after an operation, and treatment of infant respiratory distress syndrome (IRDS) of premature infants and neonates.

An object of the present invention is to provide safe therapeutic agents for asthma inhibiting the delayed type asthmatic reaction in bronchial asthma and having no side effect. The present invention is a therapeutic agents for asthma containing a compound represented by the under chemical formula or a physiologically acceptable base thereof as an effective ingredient, and the drug containing creatine or a physiologically acceptable base thereof as an effective ingredient.

An aromatic compound represented by the following formula or a pharmaceutically acceptable salt thereof:

, wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., G¹, G², G³, G⁴ and G⁵ are CH or N, X is —NH—, —O—, —CH₂—, etc., Y is —CH₂—, —CO—, —SO₂—, etc., Z is a single bond, —CO—, —SO₂—, —NH—, —O—, —S—, —CONH—, —SO₂NH—, etc., R² is hydrogen, alkyl, alkoxy, halogen, etc., and R³ is carbocyclic group, heterocyclic group, alkyl, etc.,

is useful as a controlling agent of the function of CCR4 useful for the treatment or therapy for bronchial asthma, atopic dermatitis, etc.

The invention provides a traditional Chinese medicinal preparation for treating a stable phase chronic obstructive pulmonary disease. The traditional Chinese medicinal preparation is prepared from the following medicinal materials in part by weight: 10 to 20 parts of medlar, 3 to 5 parts of prepared common monkshood daughter root, 3 to 5 parts of cinnamon, 10 to 20 parts of malaytea scurfpea fruit, 10 to 20 parts of south dodder seed, 10 to 20 parts of epimedium, 10 to 20 parts of Chinese angelica, 10 to 20 parts of red paeony root, 10 to 20 parts of szechuan lovage rhizome, 10 to 20 parts of root of rehmannia, 10 to 20 parts of amur corktree bark, 10 to 20 parts of white mulberry root bark, 20 to 30 parts of astragalus, 5 to 10 parts of liquoric root, 10 to 20 parts of aster, 5 to 10 parts of dried ginger, 5 to 10 parts of fritillary and 5 to 10 parts of peeled ginkgo seed. The traditional Chinese medicinal preparation can be prepared into formulations such as capsule preparations, granules, tablets, pills, oral liquid preparations and the like. The traditional Chinese medicinal preparation is a pure traditional Chinese medicinal preparation and does not have toxic or side effect. When the medicaments are used together, the traditional Chinese medicinal preparation has the effects of tonifying qi, nourishing yin, warming yang, supplementing lung, invigorating the spleen, nourishing kidney, relieving cough and asthma, eliminating phlegm, and treating both the symptoms and diseases. The traditional Chinese medicinal preparation has the obvious effect of treating the stable-phase chronic obstructive pulmonary disease and has the effect of treating diseases such as bronchial asthma and the like.

The invention discloses a preparation method and a quality control method of a traditional Chinese medicine preparation for treating bronchial asthma, chronic asthmatic bronchitis, emphysema and early pulmonary heart diseases. The preparation method is characterized by being a preparation method of a cough-relieving capsule as a traditional Chinese medicine preparation formed by reforming a cough-relieving tablet, optimization and screening are carried out on an extraction process, and modern new equipment and new method are adopted so as to be suitable for large-scale industrial production; the research on the quality standard is to perfect and improve on the basis of the original standard to establish a perfect method for thin bed identification and content determination so that the quality standard of a product is advanced and controllable, and the clinical effect is ensured.

The present invention relates to a kind of medicine composite for treating branchial asthma. The medicine composite consists of active component including salmeterol or its medicinal salt and budesonide in the molar ratio of 1 to 0.38-20, as well as non-active components including solvent, cosolvent, propellant, antioxidant, dilutent and lubricant. The present invention has large range of medicine dosage, long lasting period and high comprehensive effect, and may be prepared into various preparation forms.

The invention discloses Chinese herbal medicine decoction for curing bronchial asthma and a preparation method of the Chinese herbal medicine decoction. The Chinese herbal medicine decoction comprises, by weight, 9-11 parts of sophora japonica leaves, 7-9 parts of cortex lycii radicis, 3-5 parts of amethyst, 1-3 parts of cortex albiziae, 10-12 parts of cordyceps sinensis, 10-20 parts of sugarcane tops, 6-8 parts of human placenta, 8-10 parts of radix stemonae, 5-7 parts of ginseng, 2-4 parts of burdock, 9-11 parts of pomegranate blossom, 10-12 parts of beewax, 4-6 parts of stiff silkworm, 8-10 parts of cacumen biotae, 4-6 parts of fructus psoraleae, 10-15 parts of luffa stems, 3-5 parts of radix ilicis asprellae, 9-11 parts of shaddock peels and 10-12 parts of wild buckwheat. The Chinese herbal medicine decoction for curing bronchial asthma has effects of qi tonifying, lung cleaning, phlegm eliminating, spleen tonifying and qi absorption and is good in curative effect on the bronchitis, short in curing course, non-toxic and free of side effects.

The invention discloses a Bambuterol Hydrochloride oral disintegration tablet, wherein the principal drug employs Bambuterol Hydrochloride, the auxiliary materials include lactose, mannitol, crystalline cellulose, low replacement methylcellulose propylene glycol ether, cross bonding polyvinyl pyrrolidon, sodium hydrogen carbonate, citric acid, Aspartame, perfume compound, and magnesium stearate. The tablet has good treatment action for bronchial asthma, chronic bronchitis and pulmonary emphysema.

The present invention provides a prophylactic/therapeutic agent for an allergic disease caused by Th2 cell-polarized activation, which comprises at least one kind selected from a branched amino acid, glycine, serine, arginine, a keto acid thereof and a salt thereof. Because the prophylactic/therapeutic agent of the present invention produces almost no side effects, it can be safely ingested routinely and can be taken for a long time. When the prophylactic/therapeutic agent of the present invention is used in combination with an anti-inflammatory drug, the dose of the anti-inflammatory drug can be reduced. Hence, the prophylactic/therapeutic agent of the present invention is useful for the prevention or treatment of an allergic disease caused by Th2 cell-polarized activation. The prophylactic/therapeutic agent of the present invention is particularly effective on bronchial asthma and pulmonary fibrosis that accompanies bronchial asthma.

The invention discloses a medicine for treating allergic rhinitis and bronchial asthma and a preparation method thereof. The medicine is prepared by decocting aconite and liquorice according to a certain weight ratio, filtering the decoction, concentrating the filtrate, drying the concentrate, grinding the dried concentrate and adding medicinal adjuvants. The medicine is used for treating allergic rhinitis and bronchial asthma, is small in dose and less in medicinal flavor, has high efficacy and safety, low recurrence rate and good long-term efficacy, is low in cost and has good patient compliance.

The invention discloses a bronchial asthma treatment drug pillow and belongs to the traditional Chinese medicine technical field. The bronchial asthma treatment drug pillow is formed by the following raw materials of, almonds, dried tangerine or orange peel, platycodon root, honeysuckle, mint, ephedra, cloves, herba periliae, cynanchum glaucescens, ageratum, plaster stone, chrysanthemum, as arum and licorice. According to the bronchial asthma treatment drug pillow, the drug can directly act on the head, the lung can be dispersed, the phlegm can be reduced, the cough can be relieved, and accordingly the effects of lung dispersing, phlegm and pus elimination, spleen and stomach warming for cold dispelling and meridian activating for pain stopping are achieved; the bronchial asthma treatment drug pillow is suitable for the chronic bronchial asthma and the effects on the acute bronchial asthma and bronchitis are also achieved; meanwhile various disadvantages and side effects caused by the traditional treatment method are avoided and the asthma treatment effective rate reaches 98%.

A Chinese medicine for treating bronchopathy, such as bronchitis, bronchial asthma, etc is prepared from 7 Chinese-medicinal materials including loquat leaf, poppy capsule, stemona root, ephedra, etc. Its advantages are high curative effect and no toxic by-effect.

The invention discloses a traditional Chinese medicinal composition for treating bronchial asthma, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal composition is prepared from the following bulk drugs by weight: 30g of astragalus membranaceus, 30g of rhizoma atractylodis macrocephalae, 25g of divaricate saposhnikovia root, 10g of semen brassicae, 10g of honeysuckle, 10g of scutellaria baicalensis, 10g of schisandra chinensis, 10g of raw gypsum, 10g of perilla fruit, 10g of pinellia ternata, 10g of prepared rehmannia, 10g of apricot kernel, 10g of cicada slough, 10g of earthworm, 10g of dried tangerine peel, 6g of bulbus fritillariae cirrhosae, 6g of ephedra, 6g of platycodon grandiflorum, 2g of asarum, 8g of raw ginger, 5g of Chinese date, and 4g of roasted liquorice. The traditional Chinese medicinal composition has the effects on freeing lung and clearing heat, eliminating phlegm and clearing pus, warming middle-jiao and expelling cold, and calming panting and suppressing cough, fundamentally solves medical problems that asthma relapses and cannot be healed after long-time treatment, and can achieve the aim of treating both symptoms and root causes without any side effect.

The present invention relates to a kind of medicine for relieving asthma and cough and its preparation process. The medicine of the present invention has Chinese ephedra as chief medicine component, perilla leaf and bupleurum root as adjuvant medicine component, almond, dried orange peel and magnolia bark as assistant medicine components and roasted licorice as guide medicine component. The medicine has determined clinical treating effect, and the functions of promoting lung-Qi flow, relieving asthma, regulating Qi and relieving cough. The medicine may be used in treating cough and asthma caused by wind-cold as well as bronchial asthma and bronchitis.

The invention provides a medicament for treating chronic and intractable lung diseases by acupoint application and summer treatment for winter disease. The medicament is prepared by mixing and grinding white mustard seed, yanhusuo, manchurian wildginger, apricot kernel, processed ephedra herb, common curculigo rhizome and Chinese magnoliavine fruit, and adding fresh ginger juice and honey into the mixture to prepare ointment. The medicament is applied to acupoints in dog days, has definite curative effect of treating winter diseases, has the functions of warming lung and reducing phlegm, nourishing lung and arresting cough, and reinforcing kidney and relieving asthma, and can calm the lung for upper body and reinforce the kidney for the lower body so as to play a role in simultaneously treating principal and subordinate symptoms. By means of the advantages of natural climate, the medicament can fully play the therapeutic effect so as to achieve the effect of getting twice result with half the effort. Clinical effect observation of 86 chronic bronchitis patients, 92 bronchialasthma patients and 102 anaphylacticrhinitis patients proves that the total effective rate of the medicament reaches 91.8 percent, 90.2 percent and 86.2 percent respectively.

The medicine for abstention from smoking is prepared with blackberry lily rhizome, tonkin sophora root, figwort, burdock fruit, Mongolian snakegourd pericarp and other 11 kinds of Chinese medicinal materials. The medicine of the present invention has the functions of clearing away heat of pharynx and larynx, eliminating phlegm, relieving cough and asthma, benefiting vital energy and soothing the chest oppression. It can lower the nicotine content in blood to reach the aim of abstention from smoking and can eliminate nicotine, tar and other toxic matter in lung, increase elasticity of lung tissue and increase vital capacity. It may be used also for swelling and pain throat, bronchial pneumonia, bronchial asthma and many other inflammations.

The invention relates to a traditional Chinese medicine patch for the prevention and early-stage curing of bronchial asthma, and the treatment of a plurality of respiratory diseases and megrims, characterized in that the traditional Chinese medicine patch comprises, based on the weight percentage, 57 to 70 % of peach seed, 12 to 25 % of cape jasmine, 6 to 8 % of almond, and 5 to 10% of pepper. The invention has the advantages that the traditional Chinese medicine patch is mainly used for treating bronchial asthma, can cure the bronchial asthma of children at the age of below 12, and can be used in the outbreaking or catabatic period. The traditional Chinese medicine patch has the efficacy of diminishing inflammation, invigorating blood circulation, removing blood stasis, clearing away cold, relieving cough and calming panting. The traditional Chinese medicine patch can promote the synthesis of the alveolar surfactant, protect the pulmonary function to improve the lesion tissues, and can stimulate the proliferation of blood vessel endothelial cells to restore the endangium. The traditional Chinese medicine patch has the antiallergic effect, can inhibit the antiserum reaction of allergic antibody of the skin, reduce the pigment seepage and alleviate the airway obstruction. The traditional Chinese medicine patch can enhance the proliferation and conversion of T lymphocyte of spleen of a body, and improve the autoimmunity.