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Use of andrographolide compounds for treating inflammation and airway disorders

An andrographolide, airway technology, applied in the direction of anhydride/acid/halide active ingredients, anti-inflammatory agents, drug combinations, etc., can solve problems such as shortness of breath and airflow limitation

Inactive Publication Date: 2012-05-30
NAT UNIV OF SINGAPORE
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  • Abstract
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Problems solved by technology

This results in restricted airflow in and out of the lungs, causing shortness of breath

Method used

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  • Use of andrographolide compounds for treating inflammation and airway disorders
  • Use of andrographolide compounds for treating inflammation and airway disorders
  • Use of andrographolide compounds for treating inflammation and airway disorders

Examples

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Embodiment approach

[0095] We propose the use of andrographolide compounds such as andrographolide and DDA (DDAG) to supplement or replace oral steroids in airway disorders such as asthma exacerbations.

[0096] We describe a novel anti-inflammatory effect of andrographolide in asthma through inhibition of the nuclear factor-κB pathway. Sustained activation of nuclear factor (NF)-κB is associated with the development of asthma. Andrographolide, the main active ingredient of the medicinal plant Andrographis paniculata, was shown here to inhibit NF-κB activity. Andrographolide attenuates allergic asthma by inhibiting NF-κB signaling in BALB / c mice sensitized and stimulated with OVA, producing airway inflammation.

[0097] Andrographolide inhibited OVA-induced total cell count, eosinophil count, and levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid, and decreased serum levels of OVA-specific IgE. Andrographolide attenuates OVA-induced eosinophilia and airway mucus production in lung ...

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Abstract

We describe for the first time that andrographolide dirivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-kappa B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of and priority to US Provisional Patent Application No. 61 / 162,861, filed March 24, 2009, the contents of which are hereby incorporated by reference. technical field [0003] The present application relates to compounds useful in the treatment of airway disorders such as asthma and chronic obstructive pulmonary disease. Background technique [0004] Airway disorders such as asthma and chronic obstructive pulmonary disease (COPD) afflict many people. Currently, approximately 300,000,000 people in the world suffer from asthma. The incidence is expected to rise to 400,000,000 in 2025. Asthma is a common chronic lung disease of the airways that is complex and characterized by variable and recurrent symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm) and underlying inflammation. The interplay of these features of asthma determines the clinical manifestations an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/19A61P11/06A61P11/08
CPCA61K31/365A61K31/19A61P11/00A61P11/06A61P11/08A61P29/00
Inventor 黄玮韶
Owner NAT UNIV OF SINGAPORE
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