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Guanfacine sustained-release tablet and preparation method thereof

The technology of sustained-release tablet and guanidine method is applied in the field of guanfacine sustained-release tablet and its preparation, which can solve the problems of human health injury and the like, and achieve the effect of simple preparation process

Inactive Publication Date: 2012-07-04
北京万全阳光医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Disclosed in CN101252917A is the single-dose guanfacine treatment preparation of once-daily administration, which contains anionic polymer-methacrylic acid copolymer type C, as the general knowledge of pharmacy, anionic polymer-methacrylic acid copolymer Type C contains a certain amount of surfactant, the intake of surfactant will cause certain damage to human health, and has certain defects

Method used

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  • Guanfacine sustained-release tablet and preparation method thereof
  • Guanfacine sustained-release tablet and preparation method thereof
  • Guanfacine sustained-release tablet and preparation method thereof

Examples

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Abstract

The invention discloses a guanfacine sustained-release tablet and a preparation method thereof. The sustained-release tablet contains pharmaceutically-acceptable carriers and guanfacine or a pharmaceutically-acceptable salt, wherein the sustained-release tablet contains 1 to 5 parts of guanfacine, 12 to 30 parts of ethyl cellulose micropowder, 1 to 6 parts of hydroxypropyl methylcellulose, 5 to 10 parts of polyvinylpyrrolidone, 48 to 71 parts of fillers and 0.9 to 1.5 parts of lubricants. Compared with the prior art, the preparation method has a simple process, and the guanfacine sustained-release tablet can uniformly and sustainedly release guanfacine in the gastrointestinal tract regardless of gastric pH and can play a more effective role in blood sugar reduction.

Description

technical field [0001] The invention relates to a slow-release preparation of a drug for treating children and adolescents with attention deficit syndrome and a preparation method thereof, in particular to a guanfacine sustained-release tablet and a preparation method thereof. Background technique [0002] Guanfacine is a centrally acting antihypertensive drug with α2-adrenergic receptor agonist properties, and can be used as an alternative to stimulants for the treatment of ADHD Attention-deficit hyperactivity disorder. ADHD is a mental disorder that is very common in childhood. Studies have shown that most people with ADHD are due to the cerebellum not functioning properly, and ADHD does not appear alone, often combined with dyslexia, developmental coordination difficulties, and even autism, which implies multiple brain regions Or the dysfunction of a single region will affect the integration of multiple regions. ADHD is the most common psychobehavioral disorder in chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/165A61K47/38A61P25/00A61P25/28A61P9/12
Inventor 慕博吕青远
Owner 北京万全阳光医药科技有限公司
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